Ключевые слова
гуморальный иммунодефицит
аспления
St. pneumoniae
Hib
N. meningitidis
конъюгирован- ные вакцины
полисахаридные вакцины
humoral immunodeficiency
asplenia
conjugated vaccines
polysaccharide vaccines
аспления
St. pneumoniae
Hib
N. meningitidis
конъюгирован- ные вакцины
полисахаридные вакцины
humoral immunodeficiency
asplenia
conjugated vaccines
polysaccharide vaccines
Как цитировать
Пушкова Е. Вакцинация иммунокомпрометированных детей // Кремлевская медицина. Клинический вестник. 2015. Т. № 3.
Аннотация
У детей с дефектами гуморального звена иммунитета нарушена продукция антител к полисахаридным антигенамкапсульных микробов (St. pneumoniae, Hib, N. meningitidis), что может приводить к развитию смертельно опасных формданных инфекций. Вакцинация против данных инфекций является одной из самых эффективных мер специфическойпервичной профилактики. При вакцинации пациентов младше 2 лет следует использовать конъюгированные вакциныи вакцинировать детей по индивидуальному плану.In children with defects of the humoral chain in their immunity there is an impaired production of antibodies to polysaccharideantigens of capsular bacteria (Str. pneumoniae, Hib, N. meningitidis). It may lead to the development of life-threateningforms of these infections. Vaccination against these infections is one of the most effective measures of specific primaryprophylactics. Conjugated vaccines and individual vaccination plans have to be applied in children younger than two yearsof age.Литература
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response and increased B-cell population in transient
hypogammaglobulinemia of infancy. Ann. Allergy Asthma
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outcome of patients with hypogammaglobulinemia in infancy
and early childhood. J. Pediatr. 1998; 133 (1): 144–146.
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antibodies in patients with transient hypogammaglobulinemia of
infancy. J. Allergy Clin. Immunol. 1990; 85 (2): 510–513.
5. Dalal I., Roifman C.M. Hypogammaglobulinemia of
infancy. Immunol. Allergy Clin. N. Am. 2001; 21: 129–139.
6. Spickett G., Harvey J., Edwards A.J., Larson H.E. IgG1
subclass deficiency in patients with chronic fatigue syndrome.
Lancet. 1988; 30: 241.
7. Herrod H.Н. Management of patients with IgG subclass
deficiency and / or selective antibody deficiency. Ann. Allergy.
1993; 70 (1).
8. Moss R.B., Carmack M.A., Esrig S. IgG4 deficiency in
children: Association of isolated IgG4 deficiency with recurrent
infections airway. J.Pediatr. 1992; 120 (4): 161.
9. Hidalgo H., Moore C., Leiva L.E., Sorensen R.U.
Preimmunization and postimmunization pneumococcal antibody
titers in children with recurrent infections. Ann. Allergy Asthma
Immunol. 1996; 76 (4): 341–346.
10. Javier F.C., Moore C.M., Sorensen R.U. Distribution
of primary immunodeficiency diseases diagnosed in a pediatric
tertiary hospital. Ann. Allergy Asthma Immunol. 2000; 84 (4):
25–30.
11. Epstein M.M., Gruskay F. Selective deficiency in
pneumococcal antibody response in children with recurrent
infections. Ann. Allergy Asthma Immunol. 1995; 75 (3): 125–
131.
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pediatrician’s office. Pediatr. Clin. N. Am. 1994; 41 (1): 691–
714.
13. Sorensen R.U., Moore C. Antibody deficiency
syndromes. Pediatr. Clin. N. Am. 2000; 47 (3): 1225–1252.
14. Wasserman R.L., Sorensen R.U. Evaluating children
with respiratory tract infections: the role of immunization with
bacterial polysaccharide vaccine. Pediatr. Infect. Dis. J. 1999;
18 (2): 157–163.
15. Timens W., Poppema S. Impaired immune response to
polysaccharides. N. Engl. Med. J. 1987; 317: 837–839.
16. Granoff D.M., Shackelford P.G., Pandey J.P., Boies
E.G. Antibody responses to Haemophilus influenzae type b
polysaccharide vaccine in relation to Km(1) and G2m(23)
immunoglobulin allotypes. J. Infect. Dis. 1986; 154: 257–264.
17. Boyle R.J., Le C., Balloch A., Tang M.L. The clinical
syndrome of specific antibody deficiency in children. Clin. Exp.
Immunol. 2006; 146: 486–492.
18. Sorensen R.U., Leiva L.E., Javier F.C. et al. Influence
of age on the response to Streptococcus pneumonia vaccine in
patients with recurrent infections and normal immunoglobulin
concentrations. J. Allergy Clin. Immunol. 1998; 102: 215–221.
19. Di Sabatino A., Carsetti R., Corazza G.R. Postsplenectomy
and hyposplenic states. Lancet. 2011; 378: 86.
20. Rubin L.G., Schaffner W. Clinical practice. Care of the
asplenic patient. N. Engl. J. Med. 2014; 371: 349.
21. Таточенко В.К. Пневмококковая инфекция: совре-
менный взгляд на проблему и профилактику. Вопросы со-
временной педиатрии 2007; 6 (1): 5–9.
22. Kim H.S., Kriegel G., Aronson M.D. Improving the
preventive care of asplenic patients. Am. J. Med. 2012; 125: 454.
23. Регистр лекарственных средств России. М.: РЛС-
Патент, 2014.
24. Centers for Disease Control and Prevention (CDC).
Preventing pneumococcal disease among infants and young
children: recommendations of the Advisory Committee on
Immunization Practices (ACIP). MMWR. 2000; 49 (RR-9): 27.
25. Barbour M.L., Mayon-White R.T., Coles C. et al.
The impact of conjugate vaccine on carriage of Haemophilus
influenzae type b. J. Infect. Dis. 1995; 171 (1): 93–98.
26. Покровский В.И., Таточенко В.К. Гемофильная ин-
фекция. Вакцинация. 2003; 26 (2): 2.
27. Платонов А.Е., Королева И.С., Миронов К.О. Эпи-
демиология менингококковой инфекции в России и мире на
современном этапе. Вакцинация. 2004; 29 (1): 6—7.
28. Шамшева О.В., Ртищев А.Ю. Проблема менинго-
кокковой инфекции у детей: пути решения. Детские ин-
фекции. 2009; 3 (1): 31–35.
гия: Национальное руководство. М: ГЕОТАР-Медиа, 2009.
2. Dorsey M.J., Orange J.S. Impaired specific antibody
response and increased B-cell population in transient
hypogammaglobulinemia of infancy. Ann. Allergy Asthma
Immunol. 2006; 97 (5): 590–595.
3. Dalal I., Reid B., Nisbet-Brown E., Roifman C.M. The
outcome of patients with hypogammaglobulinemia in infancy
and early childhood. J. Pediatr. 1998; 133 (1): 144–146.
4. Cano F., Mayo D.R., Ballow M. Absent specific viral
antibodies in patients with transient hypogammaglobulinemia of
infancy. J. Allergy Clin. Immunol. 1990; 85 (2): 510–513.
5. Dalal I., Roifman C.M. Hypogammaglobulinemia of
infancy. Immunol. Allergy Clin. N. Am. 2001; 21: 129–139.
6. Spickett G., Harvey J., Edwards A.J., Larson H.E. IgG1
subclass deficiency in patients with chronic fatigue syndrome.
Lancet. 1988; 30: 241.
7. Herrod H.Н. Management of patients with IgG subclass
deficiency and / or selective antibody deficiency. Ann. Allergy.
1993; 70 (1).
8. Moss R.B., Carmack M.A., Esrig S. IgG4 deficiency in
children: Association of isolated IgG4 deficiency with recurrent
infections airway. J.Pediatr. 1992; 120 (4): 161.
9. Hidalgo H., Moore C., Leiva L.E., Sorensen R.U.
Preimmunization and postimmunization pneumococcal antibody
titers in children with recurrent infections. Ann. Allergy Asthma
Immunol. 1996; 76 (4): 341–346.
10. Javier F.C., Moore C.M., Sorensen R.U. Distribution
of primary immunodeficiency diseases diagnosed in a pediatric
tertiary hospital. Ann. Allergy Asthma Immunol. 2000; 84 (4):
25–30.
11. Epstein M.M., Gruskay F. Selective deficiency in
pneumococcal antibody response in children with recurrent
infections. Ann. Allergy Asthma Immunol. 1995; 75 (3): 125–
131.
12. Sorensen R.U., Moore C. Immunology in the
pediatrician’s office. Pediatr. Clin. N. Am. 1994; 41 (1): 691–
714.
13. Sorensen R.U., Moore C. Antibody deficiency
syndromes. Pediatr. Clin. N. Am. 2000; 47 (3): 1225–1252.
14. Wasserman R.L., Sorensen R.U. Evaluating children
with respiratory tract infections: the role of immunization with
bacterial polysaccharide vaccine. Pediatr. Infect. Dis. J. 1999;
18 (2): 157–163.
15. Timens W., Poppema S. Impaired immune response to
polysaccharides. N. Engl. Med. J. 1987; 317: 837–839.
16. Granoff D.M., Shackelford P.G., Pandey J.P., Boies
E.G. Antibody responses to Haemophilus influenzae type b
polysaccharide vaccine in relation to Km(1) and G2m(23)
immunoglobulin allotypes. J. Infect. Dis. 1986; 154: 257–264.
17. Boyle R.J., Le C., Balloch A., Tang M.L. The clinical
syndrome of specific antibody deficiency in children. Clin. Exp.
Immunol. 2006; 146: 486–492.
18. Sorensen R.U., Leiva L.E., Javier F.C. et al. Influence
of age on the response to Streptococcus pneumonia vaccine in
patients with recurrent infections and normal immunoglobulin
concentrations. J. Allergy Clin. Immunol. 1998; 102: 215–221.
19. Di Sabatino A., Carsetti R., Corazza G.R. Postsplenectomy
and hyposplenic states. Lancet. 2011; 378: 86.
20. Rubin L.G., Schaffner W. Clinical practice. Care of the
asplenic patient. N. Engl. J. Med. 2014; 371: 349.
21. Таточенко В.К. Пневмококковая инфекция: совре-
менный взгляд на проблему и профилактику. Вопросы со-
временной педиатрии 2007; 6 (1): 5–9.
22. Kim H.S., Kriegel G., Aronson M.D. Improving the
preventive care of asplenic patients. Am. J. Med. 2012; 125: 454.
23. Регистр лекарственных средств России. М.: РЛС-
Патент, 2014.
24. Centers for Disease Control and Prevention (CDC).
Preventing pneumococcal disease among infants and young
children: recommendations of the Advisory Committee on
Immunization Practices (ACIP). MMWR. 2000; 49 (RR-9): 27.
25. Barbour M.L., Mayon-White R.T., Coles C. et al.
The impact of conjugate vaccine on carriage of Haemophilus
influenzae type b. J. Infect. Dis. 1995; 171 (1): 93–98.
26. Покровский В.И., Таточенко В.К. Гемофильная ин-
фекция. Вакцинация. 2003; 26 (2): 2.
27. Платонов А.Е., Королева И.С., Миронов К.О. Эпи-
демиология менингококковой инфекции в России и мире на
современном этапе. Вакцинация. 2004; 29 (1): 6—7.
28. Шамшева О.В., Ртищев А.Ю. Проблема менинго-
кокковой инфекции у детей: пути решения. Детские ин-
фекции. 2009; 3 (1): 31–35.