Аннотация
Комплекс экстрофии мочевого пузыря и эписпадии представляет собой порок развития, включающий спектр врожденных аномалий мочеполовой системы, брюшной стенки, таза, мочевыводящих путей, гениталий, ануса и позвоночника. Сложная природа этого порока развития приводит к постоянным исследованиям фундаментальных научных концепций. Разъяснение этих концепций может помочь понять механизмы, лежащие в основе заболевания. Усовершенствование диагностики, тактики лечения в конечном итоге будет способствовать улучшению качества жизни пациента. В обзоре представлены современные знания об этом многофакторном заболевании, включая его фенотипические и анатомические характеристики, эпидемиологию, предлагаемые механизмы развития, существующие модели на животных и связанные с ними генетические и морфологические компоненты.
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