CONSERVATIVE REHABILITATION OF PATIENTS WITH ERECTILE DYSFUNCTION AFTER RADICAL PROSTATECTOMY
Review
Published September 4, 2023
Keywords
apparatus therapy
prostate cancer
erectile dysfunction
prostate cancer
erectile dysfunction
How to Cite
Musaev I. E., Gusakova E. V., Grushina T. I., Tkachenko G. A., Filatova E. V. CONSERVATIVE REHABILITATION OF PATIENTS WITH ERECTILE DYSFUNCTION AFTER RADICAL PROSTATECTOMY // Kremlin Medicine Journal. 2023. VOL. № 3. С. 92-95.
Abstract
Purpose. To make analytical literature review on the conservative treatment of erectile dysfunction in patients with prostate cancer after radical prostatectomy. Materials and methods. The review included data from electronic databases: Scopus, Web of Science, MedLine, Wiley, World Health Organization, the Cochrane Central Register of Controlled Trials, PubMed, elibrary, CyberLeninka, disserCat. Results. The material discusses numerous techniques and their combinations: pharmacotherapy, exercises for strengthening pelvic bottom muscles, low-intensity local extracorporeal shock wave therapy, transcranial electrical stimulation, hyperbaric oxygenation. Conclusion. The review demonstrated that for today, there are no unified approaches to the formation of the rehabilitation program for patients with prostate cancer and erectile dysfunction. Physical rehabilitation techniques are widely used, but one cannot draw a definite conclusion on the most effective one because of a large heterogeneity in study protocols.References
1. Rectile dysfunction. Clinical guidelines rubric. – 2021. In Russian. URL: https://cr.minzdrav.gov.ru/recomend/15_2?ysclid=lkkqw0av2s146489798.
2. Ramazanov K.K. et al. Comparative analysis of 10-year oncological outcomes of robot-assisted radical prostatectomy and radical retropubic prostatectomy. Experience of the Urology Clinic of the A.I. Evdokimov Moscow State University of Medicine and Dentistry // Cancer Urology. – 2023. – V. 19. – № 1. – P. 61–70. In Russian.doi: 10.17650/1726-9776-2023-19-1-61-70.
3. Pak S. et al. Changes in health-related quality of life after radical prostatectomy for prostate cancer: A longitudinal cohort study in Korea // Investig Clin Urol. – 2018. – V. 59. – № 5. – Р. 313–20. doi: 10.4111/icu.2018.59.5.313.
4. Ficarra V. et al. Systematic review and meta-analysis of studies reporting potency rates after robot-assisted radical prostatectomy // Eur Urol. – 2012. – V. 62. – № 3. – Р. 418–30. doi: 10.1016/j.eururo.2012.05.046.
5. Karnaukh P.A. et al. Preventoin and treatment of erectile dysfunction in patients after radical nervesparing prostatectomy // Urology Herald. – 2015. – № 4. – P. 50–64. In Russian. doi: 10.21886/2308-6424-2015-0-4-50-64.
6. Cao L. et al. Robot-assisted and laparoscopic vs open radical prostatectomy in clinically localized prostate cancer: perioperative, functional, and oncological outcomes. A Systematic review and meta-analysis // Medicine. – 2019. – V. 98. – № 22. – P. 15770. doi: 10.1097/MD.0000000000015770.
7. Efremov E.A. Erectile function in patients with prostate cancer // Experimental and clinical urology. – 2011. – № 2–3. P. 88–90. In Russian.
8. Goldstein I. Impotence // J. Urol. – 1994. – V. 151. – № 6. – P. 1533–4.
9. Hatzimouratidis K. et al. Pharmacotherapy for erectile dysfunction: recommendations from the Fourth International Consultation for Sexual Medicine (ICSM 2015) // J. Sex. Med. – 2016 – V. 13. – № 4. – P. 465– 488.
10. Liu C. et al. Penile rehabilitation therapy following radical prostatectomy: a meta-analysis // J. Sex. Med. – 2017. – V. 14. – № 12. – P. 1496–1503. doi: 10.1016/j.jsxm.2017.09.020.
11. Adamowicz J. et al. Tissue Engineering and Its Potential to Reduce Prostate Cancer Treatment Sequelae-Narrative Review // Front Surg. – 2021. – V. 8. – P. 644057. doi: 10.3389/fsurg.2021.644057.
12. Chung E. Regenerative technology to restore and preserve erectile function in men following prostate cancer treatment: evidence for penile rehabilitation in the context of prostate cancer survivorship // Ther Adv Urol. – 2021. – V. 13. – P. 17562872211026421. doi: 10.1177/17562872211026421.
13. Chung E. et al. Impact of physical exercise program interventions on erectile function and cardiovascular health in males with prostate cancer // World J Mens Health. – 2022. – V. 40. – № 3. – P. 361–367. doi: 10.5534/wjmh.210032.
14. Fernández R.A. et al. Improvement of continence rate with pelvic floor muscle training post-prostatectomy: A meta-analysis of randomized controlled trials // Urol Int. – 2015. – V. 94. – № 2. – P. 125–132. doi: 10.1159/000368618.
15. Goonewardene S.S. et al. A systematic review of PFE pre-prostatectomy // J Robot Surg. – 2018. – V. 12. – № 3. – P. 397–400. doi: 10.1007/s11701-018-0803-8.
16. Sayilan A.A. et al. The effect of pelvic floor muscle training on incontinence problems after radical prostatectomy // Am J Mens Health. – 2018. – V. 12. – № 4. – P. 1007–1015. doi: 10.1177/1557988318757242.
17. Myannik S.A. Recovery of erectile function in the rehabilitation program after prostate surgery: abstract of PhD Sciences. Moscow. – 2016. – 24 p. In Russian.
18. Ivanov S.S. et al. The evaluation of effectiveness of perineal muscles training in restoring erectile function // Exp Clin Urol. – 2019. – № 4. – P. 80–85. In Russian. doi: 10.29188/2222-8543-2019-11-4-80-85.
19. Karlsen R.V. et al. Couple counseling and pelvic floor muscle training for men operated for prostate cancer and for their female partners: results from the randomized procan trial // Sex Med. – 2021. – V. 9. – № 3. – P.100350. doi: 10.1016/j.esxm.2021.100350.
20. Milios J.E. et al. Pelvic floor muscle training and erectile dysfunction in radical prostatectomy: a randomized controlled trial investigating a non-invasive addition to penile rehabilitation // Sex Med. – 2020. – V. 8. – P. 414–421. doi: 10.1016/j.esxm.2020.03.005.
21. De Lira G.H.S. et al. Effects of perioperative pelvic floor muscle training on early recovery of urinary continence and erectile function in men undergoing radical prostatectomy: a randomized clinical trial // Int Braz J Urol. – 2019. – V. 45. – № 6. – P. 1196–1203. doi: 10.1590/S1677-5538.IBJU.2019.0238.
22. Chiles K.A. et al. A double-blind, randomized trial on the efficacy and safety of hyperbaric oxygenation therapy in the preservation of erectile function after radical prostatectomy // J Urol. – 2018. – V. 199. – P. 805–811. doi: 10.1016/j.juro.2017.10.016.
23. Veliev R., Veliev E., Sokolov Y. PD20-12. Hyperbaric oxygenation therapy in sexual recoveryafter radical prostatectomy // J Urol. – 2021. – V. 206. – № 3S. – P. 371–372.
24. Fode M. et al. Penile vibratory stimulation in the recovery of urinary continence and erectile function after nerve-sparing radical prostatectomy: a randomized, controlled trial // BJU Int. – 2014. – V. 114. – № 1. – P. 111–117. doi: 10.1111/bju.12501.
25. Grushina T.I. et al. Shock wave therapy in oncology: in vitro, in vivo, rehabilitation // Issues of balneology, physiotherapy and therapeutic physical culture. – 2022. – V. 99. – № 3. – P.58–65. In Russian. doi: 10.17116/kurort20229903158
26. Sighinolfi M.C. et al. Low-intensity extracorporeal shockwave therapy for the management of postprostatectomy erectile dysfunction: a systematic review of the literature // Eur Urol Open Sci. – 2022. – V. 43. – P. 45–53. doi: 10.1016/j.euros.2022.07.003.
27. Porst H. Review of the current status of low intensity extracorporeal shockwave therapy (Li-ESWT) in erectile dysfunction (ED), peyronie's disease (PD), and sexual rehabilitation after radical prostatectomy with special focus on technical aspects of the different marketed ESWT devices including personal experiences in 350 patients // Sex Med Rev. – 2021. – V. 9. – № 1. – P. 93–122. doi: 10.1016/j.sxmr.2020.01.006.
28. Sarchi L. et al. Psychological distress among patients awaiting histopathologic results after prostate biopsy: An unaddressed concern // Urol J. – 2022. – V. 89. – № 3. – P. 382–387. doi: 10.1177/03915603211049889.
29. Pompe R.S. et al. The impact of anxiety and depression on surgical and functional outcomes in patients who underwent radical prostatectomy // Eur Urol Focus. – 2018. – V. 6 – № 6. – P. 1199–1204. doi: 10.1016/j.euf.2018.12.008.
30. Occhipinti S. et al. A prospective study of psychological distress after prostate cancer surgery // Psychooncol. – 2019. – V. 28. – № 12. – P. 2389–2395. doi: 10.1002/pon.5263.
31. Nelson C.J. et al. Back to baseline: erectile function recovery after radical prostatectomy from the patients' perspective // J Sex Med. – 2013. – V. 10. – № 6. – P. 1636–1643. doi: 10.1111/jsm.12135.
32. Hoyt M.A., Carpenter K.M. Sexual self-schema and depressive symptoms after prostate cancer // Psychooncol. – 2015. – V. 24. – № 4. – P. 395–401. doi: 10.1002/pon.3601.
33. Penzhoyan A.G. et al. Increasing stress resistance by transcranial electrical stimulation in patients after prostate cancer surgery // Ul'yanovskiy mediko-biologicheskiy zhurnal. – 2022. – № 1. – P. 75–86. In Russian. doi: 10.34014/2227-1848-2022-1-75-86.
34. Troitsky M.S. et al. Possibilities of non-medicine and medicinal therapies of alert disorders (literature review) // J New Med Technol. – 2018. – V. 25. – No. 1. – P. 61–70. In Russian. doi: 10.24411/1609-2163-2018-15995.
35. Poydasheva A.G. et al. Transcranial direct current stimulation for major depression: a review // Modern therapy of mental disorders. – 2020. – № 3. – P. 44–56. In Russian. doi: 10.21265/PSYPH.2020.75.89.006.
36. Gelenberg A.J. et al. Practice guidelines for the treatment of patients with major depressive disorder. 3rd ed. Washington, DC: AРР. – 2010.
37. George M.S. et al. Brain stimulation treatments for depression // World J Biol Psychiatry. – 2014. – V. 15. – P. 167–168.
38. Vartolomei L. et al. Psychotherapeutic interventions targeting prostate cancer patients: a systematic review of the literature // Urol Oncol. – 2018. – V. 1. – № 4. – P. 283–291. doi: 10.1016/j.euo.2018.04.011.
39. Feng D. et al. Current management strategy of treating patients with erectile dysfunction after radical prostatectomy: a systematic review and meta-analysis // Int J Impot Res. – 2022. – V. 34. – № 1. – P. 18–36. doi: 10.1038/s41443-020-00364-w.
40. Mykoniatis I. et al. Assessment of combination therapies vs monotherapy for erectile dysfunction: a systematic review and meta-analysis // JAMA network open. – 2021. – V. 4. – № 2. – P. e2036337. doi: 10.1001/jamanetworkopen.2020.36337.
2. Ramazanov K.K. et al. Comparative analysis of 10-year oncological outcomes of robot-assisted radical prostatectomy and radical retropubic prostatectomy. Experience of the Urology Clinic of the A.I. Evdokimov Moscow State University of Medicine and Dentistry // Cancer Urology. – 2023. – V. 19. – № 1. – P. 61–70. In Russian.doi: 10.17650/1726-9776-2023-19-1-61-70.
3. Pak S. et al. Changes in health-related quality of life after radical prostatectomy for prostate cancer: A longitudinal cohort study in Korea // Investig Clin Urol. – 2018. – V. 59. – № 5. – Р. 313–20. doi: 10.4111/icu.2018.59.5.313.
4. Ficarra V. et al. Systematic review and meta-analysis of studies reporting potency rates after robot-assisted radical prostatectomy // Eur Urol. – 2012. – V. 62. – № 3. – Р. 418–30. doi: 10.1016/j.eururo.2012.05.046.
5. Karnaukh P.A. et al. Preventoin and treatment of erectile dysfunction in patients after radical nervesparing prostatectomy // Urology Herald. – 2015. – № 4. – P. 50–64. In Russian. doi: 10.21886/2308-6424-2015-0-4-50-64.
6. Cao L. et al. Robot-assisted and laparoscopic vs open radical prostatectomy in clinically localized prostate cancer: perioperative, functional, and oncological outcomes. A Systematic review and meta-analysis // Medicine. – 2019. – V. 98. – № 22. – P. 15770. doi: 10.1097/MD.0000000000015770.
7. Efremov E.A. Erectile function in patients with prostate cancer // Experimental and clinical urology. – 2011. – № 2–3. P. 88–90. In Russian.
8. Goldstein I. Impotence // J. Urol. – 1994. – V. 151. – № 6. – P. 1533–4.
9. Hatzimouratidis K. et al. Pharmacotherapy for erectile dysfunction: recommendations from the Fourth International Consultation for Sexual Medicine (ICSM 2015) // J. Sex. Med. – 2016 – V. 13. – № 4. – P. 465– 488.
10. Liu C. et al. Penile rehabilitation therapy following radical prostatectomy: a meta-analysis // J. Sex. Med. – 2017. – V. 14. – № 12. – P. 1496–1503. doi: 10.1016/j.jsxm.2017.09.020.
11. Adamowicz J. et al. Tissue Engineering and Its Potential to Reduce Prostate Cancer Treatment Sequelae-Narrative Review // Front Surg. – 2021. – V. 8. – P. 644057. doi: 10.3389/fsurg.2021.644057.
12. Chung E. Regenerative technology to restore and preserve erectile function in men following prostate cancer treatment: evidence for penile rehabilitation in the context of prostate cancer survivorship // Ther Adv Urol. – 2021. – V. 13. – P. 17562872211026421. doi: 10.1177/17562872211026421.
13. Chung E. et al. Impact of physical exercise program interventions on erectile function and cardiovascular health in males with prostate cancer // World J Mens Health. – 2022. – V. 40. – № 3. – P. 361–367. doi: 10.5534/wjmh.210032.
14. Fernández R.A. et al. Improvement of continence rate with pelvic floor muscle training post-prostatectomy: A meta-analysis of randomized controlled trials // Urol Int. – 2015. – V. 94. – № 2. – P. 125–132. doi: 10.1159/000368618.
15. Goonewardene S.S. et al. A systematic review of PFE pre-prostatectomy // J Robot Surg. – 2018. – V. 12. – № 3. – P. 397–400. doi: 10.1007/s11701-018-0803-8.
16. Sayilan A.A. et al. The effect of pelvic floor muscle training on incontinence problems after radical prostatectomy // Am J Mens Health. – 2018. – V. 12. – № 4. – P. 1007–1015. doi: 10.1177/1557988318757242.
17. Myannik S.A. Recovery of erectile function in the rehabilitation program after prostate surgery: abstract of PhD Sciences. Moscow. – 2016. – 24 p. In Russian.
18. Ivanov S.S. et al. The evaluation of effectiveness of perineal muscles training in restoring erectile function // Exp Clin Urol. – 2019. – № 4. – P. 80–85. In Russian. doi: 10.29188/2222-8543-2019-11-4-80-85.
19. Karlsen R.V. et al. Couple counseling and pelvic floor muscle training for men operated for prostate cancer and for their female partners: results from the randomized procan trial // Sex Med. – 2021. – V. 9. – № 3. – P.100350. doi: 10.1016/j.esxm.2021.100350.
20. Milios J.E. et al. Pelvic floor muscle training and erectile dysfunction in radical prostatectomy: a randomized controlled trial investigating a non-invasive addition to penile rehabilitation // Sex Med. – 2020. – V. 8. – P. 414–421. doi: 10.1016/j.esxm.2020.03.005.
21. De Lira G.H.S. et al. Effects of perioperative pelvic floor muscle training on early recovery of urinary continence and erectile function in men undergoing radical prostatectomy: a randomized clinical trial // Int Braz J Urol. – 2019. – V. 45. – № 6. – P. 1196–1203. doi: 10.1590/S1677-5538.IBJU.2019.0238.
22. Chiles K.A. et al. A double-blind, randomized trial on the efficacy and safety of hyperbaric oxygenation therapy in the preservation of erectile function after radical prostatectomy // J Urol. – 2018. – V. 199. – P. 805–811. doi: 10.1016/j.juro.2017.10.016.
23. Veliev R., Veliev E., Sokolov Y. PD20-12. Hyperbaric oxygenation therapy in sexual recoveryafter radical prostatectomy // J Urol. – 2021. – V. 206. – № 3S. – P. 371–372.
24. Fode M. et al. Penile vibratory stimulation in the recovery of urinary continence and erectile function after nerve-sparing radical prostatectomy: a randomized, controlled trial // BJU Int. – 2014. – V. 114. – № 1. – P. 111–117. doi: 10.1111/bju.12501.
25. Grushina T.I. et al. Shock wave therapy in oncology: in vitro, in vivo, rehabilitation // Issues of balneology, physiotherapy and therapeutic physical culture. – 2022. – V. 99. – № 3. – P.58–65. In Russian. doi: 10.17116/kurort20229903158
26. Sighinolfi M.C. et al. Low-intensity extracorporeal shockwave therapy for the management of postprostatectomy erectile dysfunction: a systematic review of the literature // Eur Urol Open Sci. – 2022. – V. 43. – P. 45–53. doi: 10.1016/j.euros.2022.07.003.
27. Porst H. Review of the current status of low intensity extracorporeal shockwave therapy (Li-ESWT) in erectile dysfunction (ED), peyronie's disease (PD), and sexual rehabilitation after radical prostatectomy with special focus on technical aspects of the different marketed ESWT devices including personal experiences in 350 patients // Sex Med Rev. – 2021. – V. 9. – № 1. – P. 93–122. doi: 10.1016/j.sxmr.2020.01.006.
28. Sarchi L. et al. Psychological distress among patients awaiting histopathologic results after prostate biopsy: An unaddressed concern // Urol J. – 2022. – V. 89. – № 3. – P. 382–387. doi: 10.1177/03915603211049889.
29. Pompe R.S. et al. The impact of anxiety and depression on surgical and functional outcomes in patients who underwent radical prostatectomy // Eur Urol Focus. – 2018. – V. 6 – № 6. – P. 1199–1204. doi: 10.1016/j.euf.2018.12.008.
30. Occhipinti S. et al. A prospective study of psychological distress after prostate cancer surgery // Psychooncol. – 2019. – V. 28. – № 12. – P. 2389–2395. doi: 10.1002/pon.5263.
31. Nelson C.J. et al. Back to baseline: erectile function recovery after radical prostatectomy from the patients' perspective // J Sex Med. – 2013. – V. 10. – № 6. – P. 1636–1643. doi: 10.1111/jsm.12135.
32. Hoyt M.A., Carpenter K.M. Sexual self-schema and depressive symptoms after prostate cancer // Psychooncol. – 2015. – V. 24. – № 4. – P. 395–401. doi: 10.1002/pon.3601.
33. Penzhoyan A.G. et al. Increasing stress resistance by transcranial electrical stimulation in patients after prostate cancer surgery // Ul'yanovskiy mediko-biologicheskiy zhurnal. – 2022. – № 1. – P. 75–86. In Russian. doi: 10.34014/2227-1848-2022-1-75-86.
34. Troitsky M.S. et al. Possibilities of non-medicine and medicinal therapies of alert disorders (literature review) // J New Med Technol. – 2018. – V. 25. – No. 1. – P. 61–70. In Russian. doi: 10.24411/1609-2163-2018-15995.
35. Poydasheva A.G. et al. Transcranial direct current stimulation for major depression: a review // Modern therapy of mental disorders. – 2020. – № 3. – P. 44–56. In Russian. doi: 10.21265/PSYPH.2020.75.89.006.
36. Gelenberg A.J. et al. Practice guidelines for the treatment of patients with major depressive disorder. 3rd ed. Washington, DC: AРР. – 2010.
37. George M.S. et al. Brain stimulation treatments for depression // World J Biol Psychiatry. – 2014. – V. 15. – P. 167–168.
38. Vartolomei L. et al. Psychotherapeutic interventions targeting prostate cancer patients: a systematic review of the literature // Urol Oncol. – 2018. – V. 1. – № 4. – P. 283–291. doi: 10.1016/j.euo.2018.04.011.
39. Feng D. et al. Current management strategy of treating patients with erectile dysfunction after radical prostatectomy: a systematic review and meta-analysis // Int J Impot Res. – 2022. – V. 34. – № 1. – P. 18–36. doi: 10.1038/s41443-020-00364-w.
40. Mykoniatis I. et al. Assessment of combination therapies vs monotherapy for erectile dysfunction: a systematic review and meta-analysis // JAMA network open. – 2021. – V. 4. – № 2. – P. e2036337. doi: 10.1001/jamanetworkopen.2020.36337.