THE EFFECT OF BROADBAND PULSED LIGHT AT THE COMPOSITION OF SKIN MICROBIOTA IN ACNE PATIENTS
Original research article
Published September 4, 2023
Keywords
broadband pulsed light
Minocycline
skin microbiota
Minocycline
skin microbiota
How to Cite
Nazarenko A. R. THE EFFECT OF BROADBAND PULSED LIGHT AT THE COMPOSITION OF SKIN MICROBIOTA IN ACNE PATIENTS // Kremlin Medicine Journal. 2023. VOL. № 3. С. 73-77.
Abstract
Up to now, the role of skin microbiota in various clinical forms of acne, as well as the impact of different curative techniques at the skin microbiota, which is involved in acne pathogenesis, have not been studied yet. So far, there is a promising technique with broadband pulsed light, which has the ability to penetrate into biological tissues and to selectively affect various structures causing anti-inflammatory and reparative effects. The light also positively impacts the skin microbiota. Purpose. To study the effectiveness of combined therapy with broadband pulsed light and low doses of Minocycline in patients with papulopustular acne of moderate severity, taking into account the composition of their skin microbiota. Materials and methods. 100 patients with papulopustular acne of moderate severity, aged 18 – 45, (women – 76%) were enrolled in the study. Disease duration varied from 1 to 15 years (average 8.9 ± 0.8 years). Two equal groups were formed depending on the initial impairments in the skin microbiota which was examined with gas chromatography-mass spectrometry (GCMS): Group 1 – skin microbiota with GCMS initially changed parameters – hypercolonization of Staphylococcus aureus and Malassezia fungi (n = 50 patients); Group 2 – skin microbiota with unchanged parameters (n = 50 patients). Each group was divided into two subgroups (25 participants in each) depending on the type of therapy: in one group participants were prescribed only medicamentous therapy – Minocycline, daily dosage 50 mg for 10 weeks and a preparation from the retinoid group for external application; in the other group participants received combined treatment – medicamentous therapy plus broadband pulsed light (once in two weeks, course of 4–6 sessions). The researchers studied correlation between impairments in the skin microbiota and the risk of post-acne scarring, as well as the influence of the combined treatment at microbiota composition. Results and conclusions. The discussed combined therapy with low doses of Minocycline and broadband pulsed light provided a positive effect at the qualitative composition of the skin microbiota in patients with initially altered GCMS indicators and does not cause negative changes in patients with initially unchanged GCMS indicators.References
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2. Acne and rosacea. – Ed. By L.S. Kruglova. – Moscow: GEOTAR-Media, 2021. – 207 p. In Russian.
3. Kokhan M.M. et al. Reasonable choice of external therapy for various forms of acne // Bulletin of Dermatology and Venereology. – 2016. – №. 2. – P. 81–86. In Russian.
4. Kruglova L.S. et al. Topical issues in the treatment of acne patients // Kremlin medicine J. – 2019. – №. 1. – P. 122–128. In Russian.
5. Dzhoraeva S.K. et al. The composition and functions of microbiocenoses of various biotopes of the macroorganism and the clinical significance of the irdisorders // Dermatology and venereology. – 2015. – №. 2. – P.5–19. In Russian.
6. Zhukova O.V. et al. Acne: current trends in patient management // Clinical dermatology and venereology. – 2016. – T. 15. – №.5. In Russian.
7. Kaibysheva V.O. et al. Human microbiome: age-related changes and functions // Evidence-based gastroenterology. – 2020. – V. 9. – №. 2. – P. 42–55. In Russian.
8. Kruglova L.S. et al. The composition of the skin microbiota in children and its impact on the pathogenesis of acne // Issues of modern pediatrics. – 2021. – V. 20. – №. 5. – P. 430–435. In Russian.
9. Beylot C. et al. Propionibacterium acnes: an update on its role in the pathogenesis of acne // J. Eur. Acad. Dermatol. Venereol. – 2014. – V. 28. – № 3. – P. 271–278.
10. Ashkenazi H. et al. Eradication of рropionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light // FEMS Immunol Med Microbiol. – 2003. – V. 35. – №. 1. – P. 17–24.
11. Parks W.C.et al. Matrix metalloproteinases as modulators of inflammation and innate immunity // Nat Rev Immunol. – 2004. – V. 4. – №. 8. – P. 617–629.
12. Dréno В.et al. Microbiome in healthy skin, update for dermatologists. J Eur Acad Dermatol Venereol. – 2016.– V. 30. – № 12. – P. 2038–2047.
13. Papageorgiou P. et al. Treatment of rosacea with intense pulsed light: significant improvement and long‐lasting results // Br J Dermatol. – 2008. – V. 159. – №. 3. – P. 628–632.
14. Percival S.L. et al. Microbiology of the skin and the role of biofilms in infection // Int Wound J. – 2012. – V. 9. – №. 1. – P. 14–32.
15. Picosse F.R. et al. Early chemabrasion for acne scars after treatment with oral isotretinoin // Dermatologic surgery. – 2012. – V. 38. – №. 9. – P. 1521–1526.
16. Rahmayani T. et al. The effect of oral probiotic on the interleukin-10 serum levels of acne vulgaris // Open access Maced J Med Sci. – 2019. – V. 7. – №. 19. – P. 3249.
17. Lou W.W.et al. Dermatologic laser surgery // Semin Cutan Med Surg. – 2002. – V. 21. – №. 2. – P. 107–128.