THE EFFECTIVENESS OF MEMBRANE PROTECTIVE THERAPY IN PATIENTS WITH ACUTE PANCREATITIS OF MODERATE SEVERITY
Original research article
Published September 2, 2023
Keywords
acute pancreatitis
membrane protectors
erythrocyte membrane
membrane protectors
erythrocyte membrane
How to Cite
Pakhomova R. A., Kochetova L. V., Gulikyan G. N., Kozlov V. V., Repin I. G. THE EFFECTIVENESS OF MEMBRANE PROTECTIVE THERAPY IN PATIENTS WITH ACUTE PANCREATITIS OF MODERATE SEVERITY // Kremlin Medicine Journal. 2023. VOL. № 3. С. 34-38.
Abstract
Purpose. To assess the impact of membrane protectors at laboratory parameters and erythrocyte membrane in patients with acute pancreatitis (AP) of moderate severity. Materials and methods. Patients with diagnosed acute pancreatitis of moderate severity were enrolled in the trial. Patients from the control group (n = 30 ) had standard treatment of acute pancreatitis generally accepted in Russia. Patients from the main group (n = 31) were prescribed membrane protector Ethylmethylhydroxypyridine succinate (Neurox) 500 mg twice a day i/v in addition to standard treatment. Both groups were comparable in age, disease severity and pancreatic lesion extension. Clinical and laboratory findings and results of atomic force microscopy (AFM) of erythrocytes were registered on admission and on days 7 and 14 after the therapy start. Results. In the main group: statistically significant decrease in sugar, creatinine, urea, blood amylase and urine amylase were registered on days 7 and 14 of treatment; AFM analysis of the erythrocyte membrane showed a statistically significant decrease in erosion/ulcer depth on days 7 and 14 and in the number of erosions/ulcers on day 14. In the control group: there was no significant decrease in laboratory parameters and improvement in the integrity of erythrocyte membrane on days 7 and 14. Membrane protectors applied in the treatment of AP patients promoted early improvement of clinical and laboratory parameters and restoration of erythrocyte membrane integrity in AP patients. Conclusion. Membrane protectors in patients with acute pancreatitis are considered to be a pathogenically substantiated method of treatment. AFM technique, which allows studying erythrocyte morphology and cytoskeleton, confirms the effectiveness of the described technique.References
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14. Pahomova R.A. et al. Morphofunctional state of erythrocytes in benign obstructive jaundice // Grekov's Bulletin of Surgery. – 2017. – V. 4. – № 176. – P. 22–26. In Russian.
15. Sherstyukova E.A. et al. Atomic force microscopy in the assessment of erythrocyte membrane mechanical properties with exposure to various physicochemical agents // Almanac of Clinical Medicine. – 2021. – V. 49. № 6. – P. 427–434. In Russian. doi: 10.18786/2072-0505-2021-49-059.
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18. Karapetjan G.E. et al. Atomic force microscopy of erythrocytes of patients with longerly non-healing wounds at the background of chronic venous failure // Medical News of North Caucasus. – 2019. – No. 1. – P. 22–25. In Russian. doi: 10.14300/mnnc.2019.14040.