ПОСТКОВИДНАЯ АНОСМИЯ: СОСТОЯНИЕ ПРОБЛЕМЫ В 2022 ГОДУ
Обзорная статья
Дата публикации: декабря 6, 2022
Ключевые слова
COVID-19
аносмия
ольфактометрия
аносмия
ольфактометрия
Как цитировать
Молодницкая А. Ю., Русецкий Ю. Ю., Тетеркина М. Н., Горбунов С. А., Муравьёва П. А. ПОСТКОВИДНАЯ АНОСМИЯ: СОСТОЯНИЕ ПРОБЛЕМЫ В 2022 ГОДУ // КРЕМЛЕВСКАЯ МЕДИЦИНА<br><i>клинический вестник</i>. 2022. Т. № 3. С. 93-98.
Аннотация
В связи с огромным количеством пациентов, перенесших COVID-19, за последние несколько лет резко увеличилось количество обращений с жалобой на затянувшееся нарушение обоняния, которая в свою очередь является серьезным симптомом, требующим тщательной дифференциальной диагностики. Данный обзор затрагивает вопросы этиологии, патогенеза, диагностики и лечения ольфакторной дисфункции, в частности - постковидной.Литература
1. Hummel T., Nordin S. Olfactory disorders and their consequences for quality of life //Acta otolaryngologica. – 2005. – V. 125. – №. 2. – P. 116-121. doi: 10.1080/00016480410022787
2. Hopkins C, Kumar N. Loss of sense of smell as marker of COVID-19 infection // London: ENT UK – 2020 – p. 65
3. Xydakis M. S. et al. Smell and taste dysfunction in patients with COVID-19 //The Lancet Infectious Diseases. – 2020. – V. 20. – №. 9. – P. 1015-1016.
4. Haehner A. et al. Predictive Value of Sudden Olfactory Loss in the Diagnosis of COVID-19 // ORL J Otorhinolaryngol Relat Spec. – 2020. – T. 82. – №4. – P. 175-180. doi: 10.1159/000509143.
5. Le Bon S. D. et al. Psychophysical evaluation of chemosensory functions 5 weeks after olfactory loss due to COVID-19: a prospective cohort study on 72 patients //European Archives of Oto-Rhino-Laryngology. – 2021. – V. 278. – №. 1. – P. 101-108. doi: 10.1007/s00405-020-06267-2.
6. Aziz M. et al. The association of «loss of smell» to COVID-19: a systematic review and meta-analysis //The American journal of the medical sciences. – 2021. – V. 361. – №. 2. – P. 216-225. doi: 10.1016/j.amjms.2020.09.017.
7. Rusetsky Y. et al. Smell Status in Children Infected with SARS‐CoV‐2 //The Laryngoscope. – 2021. – V. 131. – №. 8. – P. E2475-E2480. doi: 10.1002/lary.29403.
8. Reden J. et al. Recovery of olfactory function following closed head injury or infections of the upper respiratory tract //Archives of Otolaryngology–Head & Neck Surgery. – 2006. – V. 132. – №. 3. – P. 265-269. doi: 10.1001/archotol.132.3.265.
9. Huart C. et al. Comparison of COVID-19 and common cold chemosensory dysfunction //Rhinology. – 2020. – V. 58. – №. 6. – P. 623-625. doi: 10.4193/Rhin20.251.
10. Huart C. et al. Systemic corticosteroids in coronavirus disease 2019 (COVID‐19)‐related smell dysfunction: an international view //International forum of allergy & rhinology. – 2021. – V. 11. – №. 7. – P. 1041-1046. doi: 10.1002/alr.22788.
11. Erskine S. E., Philpott C. M. An unmet need: patients with smell and taste disorders //Clinical Otolaryngology. – 2020. – V. 45. – №. 2. – P. 197-203. doi: 10.1111/coa.13484.
12. Savvateeva D.M. Clinical features of peripheral olfactory disorders: PhD diss. – I.M. Sechenov First Moscow Medical University. – 2011. In Russian.
13. Addison, Alfred B. and Philpott, Carl M. (2018) A systematic review of therapeutic options for non-conductive olfactory dysfunction. // Otorhinolaryngologist. - 11 (2). - pp. 61-71. ISSN 1752-9360
14. Hummel T. et al. Position paper on olfactory dysfunction //Rhinology. Supplement. – 2017. – V. 54. – №. 26. doi: 10.4193/Rhino16.248.
15. Su B. et al. Clinical implications of psychophysical olfactory testing: assessment, diagnosis, and treatment outcome //Frontiers in Neuroscience. – 2021. – V. 15. – P. 301. doi: 10.3389/fnins.2021.646956.
16. Laidlaw T. M. et al. Chronic rhinosinusitis with nasal polyps and asthma //The Journal of Allergy and Clinical Immunology: In Practice. – 2021. – V. 9. – №. 3. – P. 1133-1141.doi: 10.1002/lary.24330.
17. Bugari R. A. et al. Bacterial biofilm in adults with ENT pathology //Romanian Journal of medical practice. – 2021. – V. 16. – №. 2. doi: 10.4193/Rhino14.160.
18. Pade J., Hummel T. Olfactory function following nasal surgery //The Laryngoscope. – 2008. – V. 118. – №. 7. – P. 1260-1264. doi: 10.1097/MLG.0b013e318170b5cb.
19. Pozharskaya T., Liang J., Lane A. P. Regulation of inflammation‐associated olfactory neuronal death and regeneration by the type II tumor necrosis factor receptor //International forum of allergy & rhinology. – 2013. – V. 3. – №. 9. – P. 740-747. doi: 10.1002/alr.21187.
20. Jafek B. W. et al. Biopsies of human olfactory epithelium //Chemical senses. – 2002. – V. 27. – №. 7. – P. 623-628. doi: 10.1093/chemse/27.7.623.
21. Rombaux P. et al. Olfactory bulb V.ume in patients with sinonasal disease //American journal of rhinology. – 2008. – V. 22. – №. 6. – P. 598-601. doi: 10.2500/ajr.2008.22.3237.
22. Murphy C., Doty R. L., Duncan H. J. Clinical disorders of olfaction //Handbook of olfaction and gustation. – CRC Press, 2003. – P. 822-849.
23. Suzuki M. et al. Identification of viruses in patients with postviral olfactory dysfunction //The Laryngoscope. – 2007. – V. 117. – №. 2. – P. 272-277. doi: 10.1097/01.mlg.0000249922.37381.1e.
24. Ashour H. M. et al. Insights into the recent 2019 novel coronavirus (SARS-CoV-2) in light of past human coronavirus outbreaks //Pathogens. – 2020. – V. 9. – №. 3. – P. 186. doi: 10.3390/pathogens9030186.
25. Варвянская А.В., Лопатин А.С. Проявления новой коронавирусной инфекции в верхних дыхательных путях.//Российская ринология. – 2020. – Т. 28 – №3. – С. 157-163. [Varvyanskaya AV, Lopatin AS. Evidence of new coronavirus infection in the upper respiratory tract.//Russian Rhinology. – 2020. – V. 28 – №3. – P. 157-163. In Russian]. doi: 10.17116/rosrino202028031157.
26. Van Kempen M., Bachert C., Van Cauwenberge P. An update on the pathophysiology of rhinovirus upper respiratory tract infections //Rhinology. – 1999. – V. 37. – P. 97-103.
27. Doty R.L., Mishra A. Olfaction and its alteration by nasal obstruction, rhinitis, and rhinosinusitis//Laryngoscope. – 2001. – V. 111 – №9 – P. 1673. doi: 10.1097/00005537-200103000-00008.
28. Eliezer M. et al. Sudden and complete olfactory loss function as a possible symptom of COVID-19//JAMA Otolaryngol Head Neck Surg. 2020. – V. 146 – №7 – P. 674-675. doi:10.1001/jamaoto.2020.0832.
29. Gane S.B., Kelly C., Hopkins C. Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome?//Rhinology 2020. – V. 58 – №3 – P. 299-301 doi:10.4193/Rhin20.114.
30. Kaye R. et al. COVID-19 Anosmia Reporting Tool: Initial Findings//Otolaryngol Head Neck Surg. 2020. – V. 163 – №1 – P. 132-134. doi: 10.1177/0194599820922992.
31. Printza A, Constantinidis J. The role of self-reported smell and taste disorders in suspected COVID 19//Eur Arch Otorhinolaryngol. 2020 – V. 277 – №9 – P. 2625-2630. doi: 10.1007/s00405-020-06069-6.
32. Naeini A.S. et al. Paranasal sinuses computed tomography findings in anosmia of COVID-19//Am J Otolaryngol. 2020 – V. 41 – №6 – P. 102636. doi: 10.1016/j.amjoto.2020.102636.
33. Baig A. M. et al. Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms//ACS Chem Neurosci. 2020. – V. 11 – №7 – P. 955-998. doi: 10.1021/acschemneuro.0c00122.
34. Meinhardt J. et al. Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19.//Nat Neurosci. 2021 – V. 24 – №2 – P. 168-175. doi: 10.1038/s41593-020-00758-5.
35. Brann J. H. , Firestein S. J. A lifetime of neurogenesis in the olfactory system.//Front Neurosci. 2014 – V. 26 – №8 – P. 182. doi: 10.3389/fnins.2014.00182.
36. Aragão M. F. V. V et al. Anosmia in COVID-19 Associated with Injury to the Olfactory Bulbs Evident on MRI.//AJNR Am J Neuroradiol. 2020. – V. 41 – №9 – P. 1703-1706. doi: 10.3174/ajnr.A6675.
37. Politi L. S., Salsano E., Grimaldi M. Magnetic Resonance Imaging Alteration of the Brain in a Patient With Coronavirus Disease 2019 (COVID-19) and Anosmia.//JAMA Neurol. 2020. – V. 77 – №8 – P. 1028-1029. doi: 10.1001/jamaneurol.2020.2125.
38. Brann D. H. et al. Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia.//Sci Adv. 2020. – V. 6 – №31 – P. eabc5801. doi: 10.1126/sciadv.abc5801.
39. Bilinska K. et al. Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age.//ACS Chem Neurosci. 2020. – V. 11 – №11 – P. 1555-1562. doi: 10.1021/acschemneuro.0c00210.
40. Bryche B. et al. Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters.//Brain Behav Immun. 2020. – V. 89 – P. 579-586. doi: 10.1016/j.bbi.2020.06.032.
41. Hummel T. et al. Normative data for the "Sniffin' Sticks" including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects.//Eur Arch Otorhinolaryngol. 2007. – V. 264 – №3 – P. 237-43. doi: 10.1007/s00405-006-0173-0.
42. Лопатин А.С. Современные методы исследования обонятельного анализатора. Динамика функции обоняния у пациентов с полипозным риносинуситом // Consilium Medicum. - 2014. - Т. 16. - №3. - C. 55-59. [Lopatin A.S. Sovremennye metody issledovaniya obonyatel'nogo analizatora. Dinamika funktsii obonyaniya u patsientov s polipoznym rinosinusitom // Consilium Medicum. - 2014. - V. 16. - N. 3. - P. 55-59. In Russian].
43. Овчинников Ю.М., Морозова С.В., Минор А.В. Нарушения обоняния (вопросы теории, диагностики, лечения). М.: ММА им. И.М.Сеченова, 1999. – C. 155 [Olfactory dysfunction (the issues of theory, diagnostics, treatment)]. Ovchinnikov Y. M., Morozova S. V., Minor A. V. M: MMA im I. M. Sechenova, 1999. – P. 155 In Russian].
44. Савватеева Д.М., Чучуева Н.Д. Современные методы исследования обонятельного анализатора.//Рос. ринология. 2009. – T. 4. – C. 38-42. [Savvateeva D.M., Chuchueva N.D. Modern diagnostic methods of the ilfactory analyzer// Russian Rhinology. 2009. – N. 4. – P. 38-42. In Russian].
45. Johansson L. et al. Evaluation of methods for endoscopic staging of nasal polyposis.//Acta Otolaryngol. 2000. – V. 120 – №1 – P. 72-6. doi: 10.1080/000164800760370873.
46. ENT UK at The Royal College of Surgeons of England: Management of New Onset Anosmia in the COVID Pandemic: BRS Consensus Guidelines. 2020. URL: https://www.entuk.org/sites/default/files/BRS%20COVID%20anosmia%20guidelines%20-%20recommendations%20only.pdf
47. Addison A. B. et al. Clinical Olfactory Working Group consensus statement on the treatment of postinfectious olfactory dysfunction.//J Allergy Clin Immunol. 2021. – V. 147 – №5 – P. 1704-1719. doi: 10.1016/j.jaci.2020.12.641.
48. Abdelalim A. A. et alCorticosteroid nasal spray for recovery of smell sensation in COVID-19 patients: A randomized controlled trial.//Am J Otolaryngol. 2021. – V. 42 – №2 – P. 102884. doi: 10.1016/j.amjoto.2020.102884.
49. Wu T. J., Yu A. C., Lee J. T. Management of post-COVID-19 olfactory dysfunction.//Curr Treat Options Allergy. 2022. – V. 4 – P. 1-18. doi: 10.1007/s40521-021-00297-9.
50. Whitcroft KL, Hummel T. Olfactory Dysfunction in COVID-19: Diagnosis and Management.//JAMA. 2020. – V. 323 – №24 – P. 2512-2514. doi: 10.1001/jama.2020.8391.
51. Whitcroft K. L. et al. Intranasal sodium citrate in quantitative and qualitative olfactory dysfunction: results from a prospective, controlled trial of prolonged use in 60 patients.//Eur Arch Otorhinolaryngol. 2021. – V. 278 – №8 – P. 2891-2897. doi: 10.1007/s00405-020-06567-7.
52. Hummel T., Heilmann S., Hüttenbriuk K. B. Lipoic acid in the treatment of smell dysfunction following viral infection of the upper respiratory tract.//Laryngoscope. 2002. – V. 112 – №11 – P. 2076-80. doi: 10.1097/00005537-200211000-00031.
53. Hummel T. et al. Intranasal vitamin A is beneficial in post-infectious olfactory loss.//Eur Arch Otorhinolaryngol. 2017. – V. 274 – №7 – P. 2819-2825. doi: 10.1007/s00405-017-4576-x.
54. Hernandez A. K. et al. Omega-3 supplementation in postviral olfactory dysfunction: a pilot study.//Rhinology. 2022. – V. 60 – №2 – P. 139-144 doi: 10.4193/Rhin21.378.
55. Yan C. H., Mundy D. C., Patel Z. M. The use of platelet-rich plasma in treatment of olfactory dysfunction: A pilot study.//Laryngoscope Investig Otolaryngol. 2020. – V. 5 – №2 – P. 187-193. doi: 10.1002/lio2.357.
56. Patel ZM. Oral presentation: Updates on the management of post-viral olfactory loss. ERS 2021.
57. Кокорина В.Э., Быков И.А. Оптимизация способов восстановления обоняния при аносмии, индуцированной SARS-COV-2-инфекцией.//Вестник оториноларингологии. 2022, - Т. 87 - №1 – С. 33-38. [Kokorina V.E., Bykov I.A. Optimization of methods of olfactory recovery at anosmia induced by SARS-COV-2 infection // Vestnik otorhinolaryngologii. 2022, - V. 87 - № 1 - P. 33-38. In Russian]. doi: 10.17116/otorino20228701133
58. Kronenbuerger M, Pilgramm M. Olfactory Training. - 2022.
59. Konstantinidis I., Tsakiropoulou E., Constantinidis J. Long term effects of olfactory training in patients with post-infectious olfactory loss.//Rhinology. 2016. – V. 54 – №2 – P. 170-5. doi: 10.4193/Rhino15.264.
60. Altundag A. et al. Modified olfactory training in patients with postinfectious olfactory loss.//Laryngoscope. 2015. – V. 125 – №8 – P. 1763-6. doi: 10.1002/lary.25245.
61. Damm M, Pikart LK, Reimann H, Burkert S, Göktas Ö, Haxel B, Frey S, Charalampakis I, Beule A, Renner B, Hummel T, Hüttenbrink KB. Olfactory training is helpful in postinfectious olfactory loss: a randomized, controlled, multicenter study.//Laryngoscope. 2014. – V. 124 – №4 – P. 826-31. doi: 10.1002/lary.24340.
2. Hopkins C, Kumar N. Loss of sense of smell as marker of COVID-19 infection // London: ENT UK – 2020 – p. 65
3. Xydakis M. S. et al. Smell and taste dysfunction in patients with COVID-19 //The Lancet Infectious Diseases. – 2020. – V. 20. – №. 9. – P. 1015-1016.
4. Haehner A. et al. Predictive Value of Sudden Olfactory Loss in the Diagnosis of COVID-19 // ORL J Otorhinolaryngol Relat Spec. – 2020. – T. 82. – №4. – P. 175-180. doi: 10.1159/000509143.
5. Le Bon S. D. et al. Psychophysical evaluation of chemosensory functions 5 weeks after olfactory loss due to COVID-19: a prospective cohort study on 72 patients //European Archives of Oto-Rhino-Laryngology. – 2021. – V. 278. – №. 1. – P. 101-108. doi: 10.1007/s00405-020-06267-2.
6. Aziz M. et al. The association of «loss of smell» to COVID-19: a systematic review and meta-analysis //The American journal of the medical sciences. – 2021. – V. 361. – №. 2. – P. 216-225. doi: 10.1016/j.amjms.2020.09.017.
7. Rusetsky Y. et al. Smell Status in Children Infected with SARS‐CoV‐2 //The Laryngoscope. – 2021. – V. 131. – №. 8. – P. E2475-E2480. doi: 10.1002/lary.29403.
8. Reden J. et al. Recovery of olfactory function following closed head injury or infections of the upper respiratory tract //Archives of Otolaryngology–Head & Neck Surgery. – 2006. – V. 132. – №. 3. – P. 265-269. doi: 10.1001/archotol.132.3.265.
9. Huart C. et al. Comparison of COVID-19 and common cold chemosensory dysfunction //Rhinology. – 2020. – V. 58. – №. 6. – P. 623-625. doi: 10.4193/Rhin20.251.
10. Huart C. et al. Systemic corticosteroids in coronavirus disease 2019 (COVID‐19)‐related smell dysfunction: an international view //International forum of allergy & rhinology. – 2021. – V. 11. – №. 7. – P. 1041-1046. doi: 10.1002/alr.22788.
11. Erskine S. E., Philpott C. M. An unmet need: patients with smell and taste disorders //Clinical Otolaryngology. – 2020. – V. 45. – №. 2. – P. 197-203. doi: 10.1111/coa.13484.
12. Savvateeva D.M. Clinical features of peripheral olfactory disorders: PhD diss. – I.M. Sechenov First Moscow Medical University. – 2011. In Russian.
13. Addison, Alfred B. and Philpott, Carl M. (2018) A systematic review of therapeutic options for non-conductive olfactory dysfunction. // Otorhinolaryngologist. - 11 (2). - pp. 61-71. ISSN 1752-9360
14. Hummel T. et al. Position paper on olfactory dysfunction //Rhinology. Supplement. – 2017. – V. 54. – №. 26. doi: 10.4193/Rhino16.248.
15. Su B. et al. Clinical implications of psychophysical olfactory testing: assessment, diagnosis, and treatment outcome //Frontiers in Neuroscience. – 2021. – V. 15. – P. 301. doi: 10.3389/fnins.2021.646956.
16. Laidlaw T. M. et al. Chronic rhinosinusitis with nasal polyps and asthma //The Journal of Allergy and Clinical Immunology: In Practice. – 2021. – V. 9. – №. 3. – P. 1133-1141.doi: 10.1002/lary.24330.
17. Bugari R. A. et al. Bacterial biofilm in adults with ENT pathology //Romanian Journal of medical practice. – 2021. – V. 16. – №. 2. doi: 10.4193/Rhino14.160.
18. Pade J., Hummel T. Olfactory function following nasal surgery //The Laryngoscope. – 2008. – V. 118. – №. 7. – P. 1260-1264. doi: 10.1097/MLG.0b013e318170b5cb.
19. Pozharskaya T., Liang J., Lane A. P. Regulation of inflammation‐associated olfactory neuronal death and regeneration by the type II tumor necrosis factor receptor //International forum of allergy & rhinology. – 2013. – V. 3. – №. 9. – P. 740-747. doi: 10.1002/alr.21187.
20. Jafek B. W. et al. Biopsies of human olfactory epithelium //Chemical senses. – 2002. – V. 27. – №. 7. – P. 623-628. doi: 10.1093/chemse/27.7.623.
21. Rombaux P. et al. Olfactory bulb V.ume in patients with sinonasal disease //American journal of rhinology. – 2008. – V. 22. – №. 6. – P. 598-601. doi: 10.2500/ajr.2008.22.3237.
22. Murphy C., Doty R. L., Duncan H. J. Clinical disorders of olfaction //Handbook of olfaction and gustation. – CRC Press, 2003. – P. 822-849.
23. Suzuki M. et al. Identification of viruses in patients with postviral olfactory dysfunction //The Laryngoscope. – 2007. – V. 117. – №. 2. – P. 272-277. doi: 10.1097/01.mlg.0000249922.37381.1e.
24. Ashour H. M. et al. Insights into the recent 2019 novel coronavirus (SARS-CoV-2) in light of past human coronavirus outbreaks //Pathogens. – 2020. – V. 9. – №. 3. – P. 186. doi: 10.3390/pathogens9030186.
25. Варвянская А.В., Лопатин А.С. Проявления новой коронавирусной инфекции в верхних дыхательных путях.//Российская ринология. – 2020. – Т. 28 – №3. – С. 157-163. [Varvyanskaya AV, Lopatin AS. Evidence of new coronavirus infection in the upper respiratory tract.//Russian Rhinology. – 2020. – V. 28 – №3. – P. 157-163. In Russian]. doi: 10.17116/rosrino202028031157.
26. Van Kempen M., Bachert C., Van Cauwenberge P. An update on the pathophysiology of rhinovirus upper respiratory tract infections //Rhinology. – 1999. – V. 37. – P. 97-103.
27. Doty R.L., Mishra A. Olfaction and its alteration by nasal obstruction, rhinitis, and rhinosinusitis//Laryngoscope. – 2001. – V. 111 – №9 – P. 1673. doi: 10.1097/00005537-200103000-00008.
28. Eliezer M. et al. Sudden and complete olfactory loss function as a possible symptom of COVID-19//JAMA Otolaryngol Head Neck Surg. 2020. – V. 146 – №7 – P. 674-675. doi:10.1001/jamaoto.2020.0832.
29. Gane S.B., Kelly C., Hopkins C. Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome?//Rhinology 2020. – V. 58 – №3 – P. 299-301 doi:10.4193/Rhin20.114.
30. Kaye R. et al. COVID-19 Anosmia Reporting Tool: Initial Findings//Otolaryngol Head Neck Surg. 2020. – V. 163 – №1 – P. 132-134. doi: 10.1177/0194599820922992.
31. Printza A, Constantinidis J. The role of self-reported smell and taste disorders in suspected COVID 19//Eur Arch Otorhinolaryngol. 2020 – V. 277 – №9 – P. 2625-2630. doi: 10.1007/s00405-020-06069-6.
32. Naeini A.S. et al. Paranasal sinuses computed tomography findings in anosmia of COVID-19//Am J Otolaryngol. 2020 – V. 41 – №6 – P. 102636. doi: 10.1016/j.amjoto.2020.102636.
33. Baig A. M. et al. Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms//ACS Chem Neurosci. 2020. – V. 11 – №7 – P. 955-998. doi: 10.1021/acschemneuro.0c00122.
34. Meinhardt J. et al. Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19.//Nat Neurosci. 2021 – V. 24 – №2 – P. 168-175. doi: 10.1038/s41593-020-00758-5.
35. Brann J. H. , Firestein S. J. A lifetime of neurogenesis in the olfactory system.//Front Neurosci. 2014 – V. 26 – №8 – P. 182. doi: 10.3389/fnins.2014.00182.
36. Aragão M. F. V. V et al. Anosmia in COVID-19 Associated with Injury to the Olfactory Bulbs Evident on MRI.//AJNR Am J Neuroradiol. 2020. – V. 41 – №9 – P. 1703-1706. doi: 10.3174/ajnr.A6675.
37. Politi L. S., Salsano E., Grimaldi M. Magnetic Resonance Imaging Alteration of the Brain in a Patient With Coronavirus Disease 2019 (COVID-19) and Anosmia.//JAMA Neurol. 2020. – V. 77 – №8 – P. 1028-1029. doi: 10.1001/jamaneurol.2020.2125.
38. Brann D. H. et al. Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia.//Sci Adv. 2020. – V. 6 – №31 – P. eabc5801. doi: 10.1126/sciadv.abc5801.
39. Bilinska K. et al. Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age.//ACS Chem Neurosci. 2020. – V. 11 – №11 – P. 1555-1562. doi: 10.1021/acschemneuro.0c00210.
40. Bryche B. et al. Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters.//Brain Behav Immun. 2020. – V. 89 – P. 579-586. doi: 10.1016/j.bbi.2020.06.032.
41. Hummel T. et al. Normative data for the "Sniffin' Sticks" including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects.//Eur Arch Otorhinolaryngol. 2007. – V. 264 – №3 – P. 237-43. doi: 10.1007/s00405-006-0173-0.
42. Лопатин А.С. Современные методы исследования обонятельного анализатора. Динамика функции обоняния у пациентов с полипозным риносинуситом // Consilium Medicum. - 2014. - Т. 16. - №3. - C. 55-59. [Lopatin A.S. Sovremennye metody issledovaniya obonyatel'nogo analizatora. Dinamika funktsii obonyaniya u patsientov s polipoznym rinosinusitom // Consilium Medicum. - 2014. - V. 16. - N. 3. - P. 55-59. In Russian].
43. Овчинников Ю.М., Морозова С.В., Минор А.В. Нарушения обоняния (вопросы теории, диагностики, лечения). М.: ММА им. И.М.Сеченова, 1999. – C. 155 [Olfactory dysfunction (the issues of theory, diagnostics, treatment)]. Ovchinnikov Y. M., Morozova S. V., Minor A. V. M: MMA im I. M. Sechenova, 1999. – P. 155 In Russian].
44. Савватеева Д.М., Чучуева Н.Д. Современные методы исследования обонятельного анализатора.//Рос. ринология. 2009. – T. 4. – C. 38-42. [Savvateeva D.M., Chuchueva N.D. Modern diagnostic methods of the ilfactory analyzer// Russian Rhinology. 2009. – N. 4. – P. 38-42. In Russian].
45. Johansson L. et al. Evaluation of methods for endoscopic staging of nasal polyposis.//Acta Otolaryngol. 2000. – V. 120 – №1 – P. 72-6. doi: 10.1080/000164800760370873.
46. ENT UK at The Royal College of Surgeons of England: Management of New Onset Anosmia in the COVID Pandemic: BRS Consensus Guidelines. 2020. URL: https://www.entuk.org/sites/default/files/BRS%20COVID%20anosmia%20guidelines%20-%20recommendations%20only.pdf
47. Addison A. B. et al. Clinical Olfactory Working Group consensus statement on the treatment of postinfectious olfactory dysfunction.//J Allergy Clin Immunol. 2021. – V. 147 – №5 – P. 1704-1719. doi: 10.1016/j.jaci.2020.12.641.
48. Abdelalim A. A. et alCorticosteroid nasal spray for recovery of smell sensation in COVID-19 patients: A randomized controlled trial.//Am J Otolaryngol. 2021. – V. 42 – №2 – P. 102884. doi: 10.1016/j.amjoto.2020.102884.
49. Wu T. J., Yu A. C., Lee J. T. Management of post-COVID-19 olfactory dysfunction.//Curr Treat Options Allergy. 2022. – V. 4 – P. 1-18. doi: 10.1007/s40521-021-00297-9.
50. Whitcroft KL, Hummel T. Olfactory Dysfunction in COVID-19: Diagnosis and Management.//JAMA. 2020. – V. 323 – №24 – P. 2512-2514. doi: 10.1001/jama.2020.8391.
51. Whitcroft K. L. et al. Intranasal sodium citrate in quantitative and qualitative olfactory dysfunction: results from a prospective, controlled trial of prolonged use in 60 patients.//Eur Arch Otorhinolaryngol. 2021. – V. 278 – №8 – P. 2891-2897. doi: 10.1007/s00405-020-06567-7.
52. Hummel T., Heilmann S., Hüttenbriuk K. B. Lipoic acid in the treatment of smell dysfunction following viral infection of the upper respiratory tract.//Laryngoscope. 2002. – V. 112 – №11 – P. 2076-80. doi: 10.1097/00005537-200211000-00031.
53. Hummel T. et al. Intranasal vitamin A is beneficial in post-infectious olfactory loss.//Eur Arch Otorhinolaryngol. 2017. – V. 274 – №7 – P. 2819-2825. doi: 10.1007/s00405-017-4576-x.
54. Hernandez A. K. et al. Omega-3 supplementation in postviral olfactory dysfunction: a pilot study.//Rhinology. 2022. – V. 60 – №2 – P. 139-144 doi: 10.4193/Rhin21.378.
55. Yan C. H., Mundy D. C., Patel Z. M. The use of platelet-rich plasma in treatment of olfactory dysfunction: A pilot study.//Laryngoscope Investig Otolaryngol. 2020. – V. 5 – №2 – P. 187-193. doi: 10.1002/lio2.357.
56. Patel ZM. Oral presentation: Updates on the management of post-viral olfactory loss. ERS 2021.
57. Кокорина В.Э., Быков И.А. Оптимизация способов восстановления обоняния при аносмии, индуцированной SARS-COV-2-инфекцией.//Вестник оториноларингологии. 2022, - Т. 87 - №1 – С. 33-38. [Kokorina V.E., Bykov I.A. Optimization of methods of olfactory recovery at anosmia induced by SARS-COV-2 infection // Vestnik otorhinolaryngologii. 2022, - V. 87 - № 1 - P. 33-38. In Russian]. doi: 10.17116/otorino20228701133
58. Kronenbuerger M, Pilgramm M. Olfactory Training. - 2022.
59. Konstantinidis I., Tsakiropoulou E., Constantinidis J. Long term effects of olfactory training in patients with post-infectious olfactory loss.//Rhinology. 2016. – V. 54 – №2 – P. 170-5. doi: 10.4193/Rhino15.264.
60. Altundag A. et al. Modified olfactory training in patients with postinfectious olfactory loss.//Laryngoscope. 2015. – V. 125 – №8 – P. 1763-6. doi: 10.1002/lary.25245.
61. Damm M, Pikart LK, Reimann H, Burkert S, Göktas Ö, Haxel B, Frey S, Charalampakis I, Beule A, Renner B, Hummel T, Hüttenbrink KB. Olfactory training is helpful in postinfectious olfactory loss: a randomized, controlled, multicenter study.//Laryngoscope. 2014. – V. 124 – №4 – P. 826-31. doi: 10.1002/lary.24340.