МУЖСКОЙ ФАКТОР БЕСПЛОДИЯ В АСПЕКТЕ НЕВЫНАШИВАНИЯ БЕРЕМЕННОСТИ
Обзорная статья
Дата публикации: августа 26, 2021
Ключевые слова
мужское бесплодие
невынашивание беременности
привычные потери беременности
невынашивание беременности
привычные потери беременности
Как цитировать
[1]
М. Н. Коршунов, Е. С. Коршунова, Ю. В. Кастрикин, и С. П. Даренков, МУЖСКОЙ ФАКТОР БЕСПЛОДИЯ В АСПЕКТЕ НЕВЫНАШИВАНИЯ БЕРЕМЕННОСТИ, КМКВ, вып. 3, сс. 78-82, авг. 2021.
Аннотация
Спонтанные аборты и привычные выкидыши на ранних сроках гестации составляют до 20% в структуре осложнений беременности. Основные этиологические факторы: генетические аномалии, эндокринная патология, иммунные нарушения, инфекции генитального тракта, неблагоприятные факторы образа жизни. Около 40% замерших беременностей имеют неясный генез. Обзор литературы подробно рассматривает мужской фактора бесплодия в аспекте невынашивании беременности. Представлены публикации, отражающие влияние старшего отцовского возраста, фрагментации ДНК сперматозоидов, хромосомных аномалий на исходы самостоятельных беременностей и программ вспомогательных репродуктивных технологий.Литература
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3. Li YH, Marren A. Recurrent pregnancy loss. Australian journal of general practice. //Aust J Gen Pract. – 2018. – V. 47. №. 7. – P. 432-436. doi: 10.31128/AJGP-01-18-4459.
4. Larsen E. C. et al. New insights into mechanisms behind miscarriage //BMC medicine. – 2013. – V. 11. – №. 1. – P. 1-10. doi: 10.1186/1741-7015-11-154.
5. Alegría-Torres J. A., Baccarelli A., Bollati V. Epigenetics and lifestyle //Epigenomics. – 2011. – V. 3. – №. 3. – P. 267-277. doi: 10.2217/epi.11.22.
6. Dashwood R. H., Ho E. Dietary histone deacetylase inhibitors: from cells to mice to man //Seminars in cancer biology. – Academic Press, 2007. – V. 17. – №. 5. – P. 363-369. doi: 10.1016/j.semcancer.2007.04.001.
7. Prine L., MacNaughton H. Office management of early pregnancy loss //American family physician. – 2011. – V. 84. – №. 1. – P. 75-82.
8. Santi D., Spaggiari G., Simoni M. Sperm DNA fragmentation index as a promising predictive tool for male infertility diagnosis and treatment management–meta-analyses //Reproductive biomedicine online. – 2018. – V. 37. – №. 3. – P. 315-326. doi: 10.1016/j.rbmo.2018.06.023.
9. Simon L. et al. A systematic review and meta-analysis to determine the effect of sperm DNA damage on in vitro fertilization and intracytoplasmic sperm injection outcome //Asian journal of andrology. – 2017. – V. 19. – №. 1. – P. 80. doi: 10.4103/1008-682X.
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11. Johnson S. L. et al. Consistent age-dependent declines in human semen quality: a systematic review and meta-analysis //Ageing research reviews. – 2015. – V. 19. – P. 22-33. doi: 10.1016/j.arr.2014.10.007.
12. Kleinhaus K. et al. Paternal age and spontaneous abortion //Obstetrics & Gynecology. – 2006. – V. 108. – №. 2. – P. 369-377. doi: 10.1097/01.AOG.0000224606.26514.3a.
13. Slama R. et al. Influence of paternal age on the risk of spontaneous abortion //American Journal of Epidemiology. – 2005. – V. 161. – №. 9. – P. 816-823. doi: 10.1093/aje/kwi097.
14. Selvin S., Garfinkel J. Paternal age, maternal age and birth order and the risk of a fetal loss //Human biology. – 1976. – P. 223-230.
15. Рогозин Д. С. Мужская фертильность: обзор литературы января-марта 2020 года //Вестник урологии. – 2020. – Т. 8. – №. 2. – С. 93-98. [Rogozin DS. Male fertility: literature review in January – March 2020 // Vestnik urologii (Bulletin of urology). – 2020. - V. 8 - №. 2. – P. 93-98. In Russian]. doi: 10.21886/2308-6424-2020-8-2-93-98.
16. Luna M. et al. Paternal age and assisted reproductive technology outcome in ovum recipients //Fertility and sterility. – 2009. – V. 92. – №. 5. – P. 1772-1775. doi: 10.1016/j.fertnstert.2009.05.036.
17. du Fossé N. A. et al. Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis //Human reproduction update. – 2020. – V. 26. – №. 5. – P. 650-669. doi: 10.1093/humupd/dmaa010.
18. Talebi A. R. et al. Cytochemical evaluation of sperm chromatin and DNA integrity in couples with unexplained recurrent spontaneous abortions //Andrologia. – 2012. – V. 44. – P. 462-470. doi: 10.1111/j.1439-0272.2011.01206.x.
19. Zhang L. et al. Sperm chromatin integrity may predict future fertility for unexplained recurrent spontaneous abortion patients //International journal of andrology. – 2012. – V. 35. – №. 5. – P. 752-757. doi: 10.1111/j.1365-2605.2012.01276.x.
20. Hotaling J. M. et al. The relationship between isolated teratozoospermia and clinical pregnancy after in vitro fertilization with or without intracytoplasmic sperm injection: a systematic review and meta-analysis //Fertility and sterility. – 2011. – V. 95. – №. 3. – P. 1141-1145. doi: 10.1016/j.fertnstert.2010.09.029.
21. Brahem S. et al. Semen parameters and sperm DNA fragmentation as causes of recurrent pregnancy loss //Urology. – 2011. – V. 78. – №. 4. – P. 792-796. doi: 10.1016/j.urology.2011.05.049.
22. Puscheck E. E., Jeyendran R. S. The impact of male factor on recurrent pregnancy loss //Current Opinion in Obstetrics and Gynecology. – 2007. – V. 19. – №. 3. – P. 222-228. doi: 10.1097/GCO.0b013e32813e3ff0.
23. Bronson R. Role of spermatozoa in the etiology of miscarriage //Fertility and sterility. – 2016. – V. 105. – №. 1. – P. 47-48. doi: 10.1016/j.fertnstert.2015.10.016.
24. Гамидов С. И. и др. Роль мужчины в привычном невынашивании беременности у супруги //Урология. – 2016. – №. 1-S1. – С. 35-43. [Gamidov S.I., et al. A man's role in recurrent miscarriage in a spouse. Urologija (Urology). – 2016. – №. 1-S1. – P. 35-43. In Russian].
25. Esquerré-Lamare C. et al. Sperm aneuploidy and DNA fragmentation in unexplained recurrent pregnancy loss: a multicenter case-control study //Basic and clinical andrology. – 2018. – V. 28. – №. 1. – P. 1-10. doi: 10.1186/s12610-018-0070-6.
26. Simon L. et al. Clinical significance of sperm DNA damage in assisted reproduction outcome //Human reproduction. – 2010. – V. 25. – №. 7. – P. 1594-1608. doi: 10.1093/humrep/deq103.
27. Garrido N. et al. Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility //Asian journal of andrology. – 2004. – V. 6. – №. 1. – P. 59-66.
28. Agarwal A., Cho C. L., Esteves S. C. Should we evaluate and treat sperm DNA fragmentation? //Current Opinion in Obstetrics and Gynecology. – 2016. – V. 28. – №. 3. – P. 164-171. doi: 10.1097/GCO.0000000000000271.
29. Twigg J. P., Irvine D. S., Aitken R. J. Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection //Human reproduction (Oxford, England). – 1998. – V. 13. – №. 7. – P. 1864-1871. doi: 10.1093/humrep/13.7.1864.
30. Genesca A. et al. Repair of human sperm chromosome aberrations in the hamster egg //Human genetics. – 1992. – V. 89. – №. 2. – P. 181-186. doi: 10.1007/BF00217120.
31. Коршунов М. Н., Коршунова Е. С., Даренков С. П. Прогностическая ценность показателя ДНК-фрагментации сперматозоидов в успехе программ вспомогательных репродуктивных технологий. Эмпирическая антиоксидантная терапия в коррекции ДНК-фрагментации на фоне патологического окислительного стресса эякулята //Экспериментальная и клиническая урология. – 2017. – №. 3. – C. 70-77. [Korshunov M.N., Korshunova E.S., Darenkov S.P. Predictive value of DNA fragmentation index in sperm cells for the success of assisteted reprodactive techniques. Empirical antioxidant therapy for the correction of DNA fragmentation in the setting of pathological oxidative stress of the ejaculate // Jeksperimental'naja i klinicheskaja urologija (Experimental and Clinical Urology). – 2017. – №. 3. – P. 70-77. In Russian].
32. McQueen D. B., Zhang J., Robins J. C. Sperm DNA fragmentation and recurrent pregnancy loss: a systematic review and meta-analysis //Fertility and sterility. – 2019. – V. 112. – №. 1. – P. 54-60. doi: 10.1016/j.fertnstert.2019.03.003.
33. Gihan M Bareh et al. Sperm deoxyribonucleic acid fragmentation assessment in normozoospermic male partners of couples with unexplained recurrent pregnancy loss: a prospective study. //Fertil Steril. – 2016. – V. 105. – №. 2. – P. 329-36. doi: 10.1016/j.fertnstert.2015.10.033.
34. Carrell D. T. et al. Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss //Archives of andrology. – 2003. – V. 49. – №. 1. – P. 49-55. doi: 10.1080/01485010290099390.
35. Zini A. et al. Sperm DNA damage is associated with an increased risk of pregnancy loss after IVF and ICSI: systematic review and meta-analysis //Human reproduction. – 2008. – V. 23. – №. 12. – P. 2663-2668. doi: 10.1093/humrep/den321.
36. Zhao J. et al. Whether sperm deoxyribonucleic acid fragmentation has an effect on pregnancy and miscarriage after in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis //Fertility and sterility. – 2014. – V. 102. – №. 4. – P. 998-1005. doi: 10.1016/j.fertnstert.2014.06.033.
37. Casanovas A. et al. Double-stranded sperm DNA damage is a cause of delay in embryo development and can impair implantation rates //Fertility and sterility. – 2019. – V. 111. – №. 4. – P. 699-707. doi: 10.1016/j.fertnstert.2018.11.035.
38. Pons I. et al. One abstinence day decreases sperm DNA fragmentation in 90% of selected patients //Journal of assisted reproduction and genetics. – 2013. – V. 30. – №. 9. – P. 1211-1218. doi: 10.1007/s10815-013-0089-8.
2. Kaser D. The status of genetic screening in recurrent pregnancy loss //Obstetrics and Gynecology Clinics. – 2018. – V. 45. – №. 1. – P. 143-154. doi: 10.1016/j.ogc.2017.10.007.
3. Li YH, Marren A. Recurrent pregnancy loss. Australian journal of general practice. //Aust J Gen Pract. – 2018. – V. 47. №. 7. – P. 432-436. doi: 10.31128/AJGP-01-18-4459.
4. Larsen E. C. et al. New insights into mechanisms behind miscarriage //BMC medicine. – 2013. – V. 11. – №. 1. – P. 1-10. doi: 10.1186/1741-7015-11-154.
5. Alegría-Torres J. A., Baccarelli A., Bollati V. Epigenetics and lifestyle //Epigenomics. – 2011. – V. 3. – №. 3. – P. 267-277. doi: 10.2217/epi.11.22.
6. Dashwood R. H., Ho E. Dietary histone deacetylase inhibitors: from cells to mice to man //Seminars in cancer biology. – Academic Press, 2007. – V. 17. – №. 5. – P. 363-369. doi: 10.1016/j.semcancer.2007.04.001.
7. Prine L., MacNaughton H. Office management of early pregnancy loss //American family physician. – 2011. – V. 84. – №. 1. – P. 75-82.
8. Santi D., Spaggiari G., Simoni M. Sperm DNA fragmentation index as a promising predictive tool for male infertility diagnosis and treatment management–meta-analyses //Reproductive biomedicine online. – 2018. – V. 37. – №. 3. – P. 315-326. doi: 10.1016/j.rbmo.2018.06.023.
9. Simon L. et al. A systematic review and meta-analysis to determine the effect of sperm DNA damage on in vitro fertilization and intracytoplasmic sperm injection outcome //Asian journal of andrology. – 2017. – V. 19. – №. 1. – P. 80. doi: 10.4103/1008-682X.
10. Sakkas D., Alvarez J. G. Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis //Fertility and sterility. – 2010. – V. 93. – №. 4. – P. 1027-1036. doi: 10.1016/j.fertnstert.2009.10.046.
11. Johnson S. L. et al. Consistent age-dependent declines in human semen quality: a systematic review and meta-analysis //Ageing research reviews. – 2015. – V. 19. – P. 22-33. doi: 10.1016/j.arr.2014.10.007.
12. Kleinhaus K. et al. Paternal age and spontaneous abortion //Obstetrics & Gynecology. – 2006. – V. 108. – №. 2. – P. 369-377. doi: 10.1097/01.AOG.0000224606.26514.3a.
13. Slama R. et al. Influence of paternal age on the risk of spontaneous abortion //American Journal of Epidemiology. – 2005. – V. 161. – №. 9. – P. 816-823. doi: 10.1093/aje/kwi097.
14. Selvin S., Garfinkel J. Paternal age, maternal age and birth order and the risk of a fetal loss //Human biology. – 1976. – P. 223-230.
15. Рогозин Д. С. Мужская фертильность: обзор литературы января-марта 2020 года //Вестник урологии. – 2020. – Т. 8. – №. 2. – С. 93-98. [Rogozin DS. Male fertility: literature review in January – March 2020 // Vestnik urologii (Bulletin of urology). – 2020. - V. 8 - №. 2. – P. 93-98. In Russian]. doi: 10.21886/2308-6424-2020-8-2-93-98.
16. Luna M. et al. Paternal age and assisted reproductive technology outcome in ovum recipients //Fertility and sterility. – 2009. – V. 92. – №. 5. – P. 1772-1775. doi: 10.1016/j.fertnstert.2009.05.036.
17. du Fossé N. A. et al. Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis //Human reproduction update. – 2020. – V. 26. – №. 5. – P. 650-669. doi: 10.1093/humupd/dmaa010.
18. Talebi A. R. et al. Cytochemical evaluation of sperm chromatin and DNA integrity in couples with unexplained recurrent spontaneous abortions //Andrologia. – 2012. – V. 44. – P. 462-470. doi: 10.1111/j.1439-0272.2011.01206.x.
19. Zhang L. et al. Sperm chromatin integrity may predict future fertility for unexplained recurrent spontaneous abortion patients //International journal of andrology. – 2012. – V. 35. – №. 5. – P. 752-757. doi: 10.1111/j.1365-2605.2012.01276.x.
20. Hotaling J. M. et al. The relationship between isolated teratozoospermia and clinical pregnancy after in vitro fertilization with or without intracytoplasmic sperm injection: a systematic review and meta-analysis //Fertility and sterility. – 2011. – V. 95. – №. 3. – P. 1141-1145. doi: 10.1016/j.fertnstert.2010.09.029.
21. Brahem S. et al. Semen parameters and sperm DNA fragmentation as causes of recurrent pregnancy loss //Urology. – 2011. – V. 78. – №. 4. – P. 792-796. doi: 10.1016/j.urology.2011.05.049.
22. Puscheck E. E., Jeyendran R. S. The impact of male factor on recurrent pregnancy loss //Current Opinion in Obstetrics and Gynecology. – 2007. – V. 19. – №. 3. – P. 222-228. doi: 10.1097/GCO.0b013e32813e3ff0.
23. Bronson R. Role of spermatozoa in the etiology of miscarriage //Fertility and sterility. – 2016. – V. 105. – №. 1. – P. 47-48. doi: 10.1016/j.fertnstert.2015.10.016.
24. Гамидов С. И. и др. Роль мужчины в привычном невынашивании беременности у супруги //Урология. – 2016. – №. 1-S1. – С. 35-43. [Gamidov S.I., et al. A man's role in recurrent miscarriage in a spouse. Urologija (Urology). – 2016. – №. 1-S1. – P. 35-43. In Russian].
25. Esquerré-Lamare C. et al. Sperm aneuploidy and DNA fragmentation in unexplained recurrent pregnancy loss: a multicenter case-control study //Basic and clinical andrology. – 2018. – V. 28. – №. 1. – P. 1-10. doi: 10.1186/s12610-018-0070-6.
26. Simon L. et al. Clinical significance of sperm DNA damage in assisted reproduction outcome //Human reproduction. – 2010. – V. 25. – №. 7. – P. 1594-1608. doi: 10.1093/humrep/deq103.
27. Garrido N. et al. Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility //Asian journal of andrology. – 2004. – V. 6. – №. 1. – P. 59-66.
28. Agarwal A., Cho C. L., Esteves S. C. Should we evaluate and treat sperm DNA fragmentation? //Current Opinion in Obstetrics and Gynecology. – 2016. – V. 28. – №. 3. – P. 164-171. doi: 10.1097/GCO.0000000000000271.
29. Twigg J. P., Irvine D. S., Aitken R. J. Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection //Human reproduction (Oxford, England). – 1998. – V. 13. – №. 7. – P. 1864-1871. doi: 10.1093/humrep/13.7.1864.
30. Genesca A. et al. Repair of human sperm chromosome aberrations in the hamster egg //Human genetics. – 1992. – V. 89. – №. 2. – P. 181-186. doi: 10.1007/BF00217120.
31. Коршунов М. Н., Коршунова Е. С., Даренков С. П. Прогностическая ценность показателя ДНК-фрагментации сперматозоидов в успехе программ вспомогательных репродуктивных технологий. Эмпирическая антиоксидантная терапия в коррекции ДНК-фрагментации на фоне патологического окислительного стресса эякулята //Экспериментальная и клиническая урология. – 2017. – №. 3. – C. 70-77. [Korshunov M.N., Korshunova E.S., Darenkov S.P. Predictive value of DNA fragmentation index in sperm cells for the success of assisteted reprodactive techniques. Empirical antioxidant therapy for the correction of DNA fragmentation in the setting of pathological oxidative stress of the ejaculate // Jeksperimental'naja i klinicheskaja urologija (Experimental and Clinical Urology). – 2017. – №. 3. – P. 70-77. In Russian].
32. McQueen D. B., Zhang J., Robins J. C. Sperm DNA fragmentation and recurrent pregnancy loss: a systematic review and meta-analysis //Fertility and sterility. – 2019. – V. 112. – №. 1. – P. 54-60. doi: 10.1016/j.fertnstert.2019.03.003.
33. Gihan M Bareh et al. Sperm deoxyribonucleic acid fragmentation assessment in normozoospermic male partners of couples with unexplained recurrent pregnancy loss: a prospective study. //Fertil Steril. – 2016. – V. 105. – №. 2. – P. 329-36. doi: 10.1016/j.fertnstert.2015.10.033.
34. Carrell D. T. et al. Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss //Archives of andrology. – 2003. – V. 49. – №. 1. – P. 49-55. doi: 10.1080/01485010290099390.
35. Zini A. et al. Sperm DNA damage is associated with an increased risk of pregnancy loss after IVF and ICSI: systematic review and meta-analysis //Human reproduction. – 2008. – V. 23. – №. 12. – P. 2663-2668. doi: 10.1093/humrep/den321.
36. Zhao J. et al. Whether sperm deoxyribonucleic acid fragmentation has an effect on pregnancy and miscarriage after in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis //Fertility and sterility. – 2014. – V. 102. – №. 4. – P. 998-1005. doi: 10.1016/j.fertnstert.2014.06.033.
37. Casanovas A. et al. Double-stranded sperm DNA damage is a cause of delay in embryo development and can impair implantation rates //Fertility and sterility. – 2019. – V. 111. – №. 4. – P. 699-707. doi: 10.1016/j.fertnstert.2018.11.035.
38. Pons I. et al. One abstinence day decreases sperm DNA fragmentation in 90% of selected patients //Journal of assisted reproduction and genetics. – 2013. – V. 30. – №. 9. – P. 1211-1218. doi: 10.1007/s10815-013-0089-8.