САРКОПЕНИЯ: ВЗГЛЯД АНЕСТЕЗИОЛОГА-РЕАНИМАТОЛОГА
Обзорная статья
Дата публикации: апреля 21, 2021
Ключевые слова
саркопения
нутритивная недостаточность
нутритивная недостаточность
Как цитировать
Пасечник И. Н., Закревский А. И., Талызин П. А., Мазова М. С. САРКОПЕНИЯ: ВЗГЛЯД АНЕСТЕЗИОЛОГА-РЕАНИМАТОЛОГА // Кремлевская медицина. Клинический вестник.. 2021. Т. № 1. С. 82-89.
Аннотация
В статье обсуждаются вопросы эпидемиологии, диагностики и механизмов развития саркопении – состояния, связанного с возрастным снижением массы мышечной ткани, а также ее функциональными изменениями. Рассмотрено влияние саркопении на прогноз в различных когортах больных, требующих проведения интенсивной терапии. Особое внимание уделяется оптимизации терапии пациентов с саркопенией на основе высокобелковой нутритивной поддержки. Данный подход к терапии пациентов с саркопенией является многообещающим, но для определения влияния данной тактики на внутрибольничную смертность и функциональные исходы требуется проведение дальнейших исследований.Литература
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2. Григорьева И. И. и др. Саркопения: особенности патогенеза и диагностики //Фундаментальная и клиническая медицина. – 2019. – V. 4. – №. 4. [Grigorieva I.I., Raskina T.A., Letaeva M.V., Malyshenko O.S., Averkieva Yu.V., Masenko V.L., Kokov A.N. Sarcopenia: pathogenesis and diagnosis// Fundamental and Clinical Medicine. 2019 – 4(4) – 105-116 – In Russian] doi:10.23946/2500-0764-2019-4-4-105-116
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4. Cruz-Jentoft A. J. et al. Sarcopenia: revised European consensus on definition and diagnosis //Age and ageing. – 2019. – V. 48. – №. 1. – P. 16-31.
5. Scharf G., Heineke J. Finding good biomarkers for sarcopenia. – 2012.
6. Darvall J. N. et al. Frailty indexes in perioperative and critical care: a systematic review //Archives of gerontology and geriatrics. – 2018. – V. 79. – P. 88-96.
7. Malmstrom T. K., Morley J. E. SARC-F: a simple questionnaire to rapidly diagnose sarcopenia //Journal of the American Medical Directors Association. – 2013. – V. 14. – №. 8. – P. 531-532.
8. Weijs P. J. M. et al. Low skeletal muscle area is a risk factor for mortality in mechanically ventilated critically ill patients //Critical care. – 2014. – V. 18. – №. 1. – P. 1-7.
9. Шостак Н. А., Мурадянц А. А., Кондрашов А. А. Саркопения и перекрестные синдромы–значение в клинической практике //Клиницист. – 2016. – V. 10. – №. 3. [Shostak N.A., Muradyantz A.A., Kondrashov A.A. SARCOPENIA AND OVERLAPPING SYNDROMES: THEIR VALUE IN CLINICAL PRACTICE //The Clinician – 2016 – 10(3) – 10-14. In Russian. https://doi.org/10.17650/1818-8338-2016-10-3-10-14
10. Burton L. A., Sumukadas D. Optimal management of sarcopenia //Clinical interventions in aging. – 2010. – V. 5. – P. 217.
11. Kaji H. Interaction between muscle and bone //Journal of bone metabolism. – 2014. – V. 21. – №. 1. – P. 29.
12. Kaji H. Effects of myokines on bone //BoneKEy reports. – 2016. – V. 5.
13. Atkins J. L. et al. Sarcopenic obesity and risk of cardiovascular disease and mortality: a population‐based cohort study of older men //Journal of the American Geriatrics Society. – 2014. – V. 62. – №. 2. – P. 253-260.
14. Lee I., Ha C., Kang H. Association of sarcopenia and physical activity with femur bone mineral density in elderly women //Journal of exercise nutrition & biochemistry. – 2016. – V. 20. – №. 1. – P. 23.
15. Choi K. M. Sarcopenia and sarcopenic obesity //The Korean journal of internal medicine. – 2016. – V. 31. – №. 6. – P. 1054.
16. Setiati S. Diagnostic Tools for Sarcopenia: Can We Get Less Expensive and Accurate Methods? //Acta Medica Indonesiana. – 2019. – V. 51. – №. 2. – P. 93.
17. Visvanathan R. et al. Appendicular Skeletal Muscle Mass: Development and Validation of Anthropometric Prediction Equations //The Journal of frailty & aging. – 2012. – V. 1. – №. 4. – P. 147-151.
18. Yu S. et al. An anthropometric prediction equation for appendicular skeletal muscle mass in combination with a measure of muscle function to screen for sarcopenia in primary and aged care //Journal of the American Medical Directors Association. – 2015. – V. 16. – №. 1. – P. 25-30.
19. Newman A. B. et al. Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort //The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. – 2006. – V. 61. – №. 1. – P. 72-77.
20. Lauretani F. et al. Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia //Journal of applied physiology. – 2003.
21. Guglielmi G. et al. The role of DXA in sarcopenia //Aging clinical and experimental research. – 2016. – V. 28. – №. 6. – P. 1047-1060.
22. Gonzalez M. C., Heymsfield S. B. Bioelectrical impedance analysis for diagnosing sarcopenia and cachexia: what are we really estimating?. – 2017.
23. Lee K. et al. Recent issues on body composition imaging for sarcopenia evaluation //Korean journal of radiology. – 2019. – V. 20. – №. 2. – P. 205.
24. Stringer H. J., Wilson D. The role of ultrasound as a diagnostic tool for sarcopenia //The Journal of frailty & aging. – 2018. – V. 7. – №. 4. – P. 258-261.
25. Perkisas S. et al. Application of ultrasound for muscle assessment in sarcopenia: towards standardized measurements //European geriatric medicine. – 2018. – V. 9. – №. 6. – P. 739-757.
26. Puthucheary Z. A. et al. Acute skeletal muscle wasting in critical illness //Jama. – 2013. – V. 310. – №. 15. – P. 1591-1600.
27. Cesari M. et al. Biomarkers of sarcopenia in clinical trials—recommendations from the International Working Group on Sarcopenia //Journal of cachexia, sarcopenia and muscle. – 2012. – V. 3. – №. 3. – P. 181-190.
28. Ali N. A. et al. Acquired weakness, handgrip strength, and mortality in critically ill patients //American journal of respiratory and critical care medicine. – 2008. – V. 178. – №. 3. – P. 261-268.
29. De Jonghe B. et al. Respiratory weakness is associated with limb weakness and delayed weaning in critical illness //Critical care medicine. – 2007. – V. 35. – №. 9.
30. Wieske L. et al. Impact of ICU-acquired weakness on post-ICU physical functioning: a follow-up study //Critical Care. – 2015. – V. 19. – №. 1. – P. 1-8.
31. Iwashyna T. J. et al. Long-term cognitive impairment and functional disability among survivors of severe sepsis //Jama. – 2010. – V. 304. – №. 16. – P. 1787-1794.
32. Khan I. M. et al. Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance //International journal of obesity. – 2015. – V. 39. – №. 11. – P. 1607-1618.
33. Lee D. E. et al. Getting the message across: mechanisms of physiological cross talk by adipose tissue //American Journal of Physiology-Endocrinology and Metabolism. – 2009. – V. 296. – №. 6. – P. E1210-E1229.
34. Addison O. et al. Intermuscular fat: a review of the consequences and causes //International journal of endocrinology. – 2014. – V. 2014.
35. Coen P. M., Goodpaster B. H. Role of intramyocelluar lipids in human health //Trends in Endocrinology & Metabolism. – 2012. – V. 23. – №. 8. – P. 391-398.
36. Kizilarslanoglu M. C. et al. Sarcopenia in critically ill patients //Journal of anesthesia. – 2016. – V. 30. – №. 5. – P. 884-890.
37. Wollersheim T. et al. Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness //Intensive care medicine. – 2014. – V. 40. – №. 4. – P. 528-538.
38. Toptas M. et al. The relation between sarcopenia and mortality in patients at intensive care unit //BioMed research international. – 2018. – V. 2018.
39. Zuckerman J. et al. Psoas muscle area and length of stay in older adults undergoing cardiac operations //The Annals of thoracic surgery. – 2017. – V. 103. – №. 5. – P. 1498-1504.
40. Weijs P. J. M. et al. Optimal protein and energy nutrition decreases mortality in mechanically ventilated, critically ill patients: a prospective observational cohort study //Journal of parenteral and enteral nutrition. – 2012. – V. 36. – №. 1. – P. 60-68.
41. Allingstrup M. J. et al. Provision of protein and energy in relation to measured requirements in intensive care patients //Clinical Nutrition. – 2012. – V. 31. – №. 4. – P. 462-468.
42. Hernández-Tejedor A. et al. Recommendations of the Working Groups from the Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC) for the management of adult critically ill patients //Medicina Intensiva (English Edition). – 2017. – V. 41. – №. 5. – P. 285-305.
43. Hoffer L. J., Bistrian B. R. What is the best nutritional support for critically ill patients? //Hepatobiliary surgery and nutrition. – 2014. – V. 3. – №. 4. – P. 172.
44. Segadilha N. L. A. L. et al. Energy expenditure in critically ill elderly patients: indirect calorimetry vs predictive equations //Journal of Parenteral and Enteral Nutrition. – 2017. – V. 41. – №. 5. – P. 776-784.
45. Kayambu G., Boots R., Paratz J. Physical therapy for the critically ill in the ICU: a systematic review and meta-analysis //Read Online: Critical Care Medicine| Society of Critical Care Medicine. – 2013. – V. 41. – №. 6. – P. 1543-1554.
46. Bhasin S. Testosterone supplementation and aging-associated sarcopenia //Endocrine Aspects of Successful Aging: Genes, Hormones and Lifestyles. – 2004. – P. 175-190.
47. BHASIN S., BUCKWALTER J. G. Testosterone supplementation in older men: a rational idea whose time has not yet come //Journal of andrology. – 2001. – V. 22. – №. 5. – P. 718-731.
48. Matsumoto A. M. Andropause: clinical implications of the decline in serum testosterone levels with aging in men //The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. – 2002. – V. 57. – №. 2. – P. M76-M99.
49. Rudman D. et al. Effects of human growth hormone in men over 60 years old //New England Journal of Medicine. – 1990. – V. 323. – №. 1. – P. 1-6.
50. Papadakis M. A. et al. Growth hormone replacement in healthy older men improves body composition but not functional ability //Annals of internal medicine. – 1996. – V. 124. – №. 8. – P. 708-716.
51. Yarasheski K. E., Zachwieja J. J. Growth hormone therapy for the elderly: the fountain of youth proves toxic //Jama. – 1993. – V. 270. – №. 14. – P. 1694-1694. Side effects resulting from the use of growth hormone and insulin-like growth factor-I as combined therapy to frail elderly patients. //J Gerontol – 1998 –53 – 183–7. doi: 10.1093/gerona/53a.3.m183
52. Bonafé L. et al. Carnitine deficiency in chronic critical illness //Current Opinion in Clinical Nutrition & Metabolic Care. – 2014. – V. 17. – №. 2. – P. 200-209.
53. Holeček M. Beta‐hydroxy‐beta‐methylbutyrate supplementation and skeletal muscle in healthy and muscle‐wasting conditions //Journal of cachexia, sarcopenia and muscle. – 2017. – V. 8. – №. 4. – P. 529-541.
54. Morley J. E. Pharmacologic options for the treatment of sarcopenia //Calcified tissue international. – 2016. – V. 98. – №. 4. – P. 319-333.
2. Григорьева И. И. и др. Саркопения: особенности патогенеза и диагностики //Фундаментальная и клиническая медицина. – 2019. – V. 4. – №. 4. [Grigorieva I.I., Raskina T.A., Letaeva M.V., Malyshenko O.S., Averkieva Yu.V., Masenko V.L., Kokov A.N. Sarcopenia: pathogenesis and diagnosis// Fundamental and Clinical Medicine. 2019 – 4(4) – 105-116 – In Russian] doi:10.23946/2500-0764-2019-4-4-105-116
3. Rosenburg I. Summary comments: epidemiological and methodological problems in determining nutritional status of older persons //American Journal of Clinical Nutrition. – 1989. – V. 50. – №. 5. – P. 1231-1233.
4. Cruz-Jentoft A. J. et al. Sarcopenia: revised European consensus on definition and diagnosis //Age and ageing. – 2019. – V. 48. – №. 1. – P. 16-31.
5. Scharf G., Heineke J. Finding good biomarkers for sarcopenia. – 2012.
6. Darvall J. N. et al. Frailty indexes in perioperative and critical care: a systematic review //Archives of gerontology and geriatrics. – 2018. – V. 79. – P. 88-96.
7. Malmstrom T. K., Morley J. E. SARC-F: a simple questionnaire to rapidly diagnose sarcopenia //Journal of the American Medical Directors Association. – 2013. – V. 14. – №. 8. – P. 531-532.
8. Weijs P. J. M. et al. Low skeletal muscle area is a risk factor for mortality in mechanically ventilated critically ill patients //Critical care. – 2014. – V. 18. – №. 1. – P. 1-7.
9. Шостак Н. А., Мурадянц А. А., Кондрашов А. А. Саркопения и перекрестные синдромы–значение в клинической практике //Клиницист. – 2016. – V. 10. – №. 3. [Shostak N.A., Muradyantz A.A., Kondrashov A.A. SARCOPENIA AND OVERLAPPING SYNDROMES: THEIR VALUE IN CLINICAL PRACTICE //The Clinician – 2016 – 10(3) – 10-14. In Russian. https://doi.org/10.17650/1818-8338-2016-10-3-10-14
10. Burton L. A., Sumukadas D. Optimal management of sarcopenia //Clinical interventions in aging. – 2010. – V. 5. – P. 217.
11. Kaji H. Interaction between muscle and bone //Journal of bone metabolism. – 2014. – V. 21. – №. 1. – P. 29.
12. Kaji H. Effects of myokines on bone //BoneKEy reports. – 2016. – V. 5.
13. Atkins J. L. et al. Sarcopenic obesity and risk of cardiovascular disease and mortality: a population‐based cohort study of older men //Journal of the American Geriatrics Society. – 2014. – V. 62. – №. 2. – P. 253-260.
14. Lee I., Ha C., Kang H. Association of sarcopenia and physical activity with femur bone mineral density in elderly women //Journal of exercise nutrition & biochemistry. – 2016. – V. 20. – №. 1. – P. 23.
15. Choi K. M. Sarcopenia and sarcopenic obesity //The Korean journal of internal medicine. – 2016. – V. 31. – №. 6. – P. 1054.
16. Setiati S. Diagnostic Tools for Sarcopenia: Can We Get Less Expensive and Accurate Methods? //Acta Medica Indonesiana. – 2019. – V. 51. – №. 2. – P. 93.
17. Visvanathan R. et al. Appendicular Skeletal Muscle Mass: Development and Validation of Anthropometric Prediction Equations //The Journal of frailty & aging. – 2012. – V. 1. – №. 4. – P. 147-151.
18. Yu S. et al. An anthropometric prediction equation for appendicular skeletal muscle mass in combination with a measure of muscle function to screen for sarcopenia in primary and aged care //Journal of the American Medical Directors Association. – 2015. – V. 16. – №. 1. – P. 25-30.
19. Newman A. B. et al. Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort //The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. – 2006. – V. 61. – №. 1. – P. 72-77.
20. Lauretani F. et al. Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia //Journal of applied physiology. – 2003.
21. Guglielmi G. et al. The role of DXA in sarcopenia //Aging clinical and experimental research. – 2016. – V. 28. – №. 6. – P. 1047-1060.
22. Gonzalez M. C., Heymsfield S. B. Bioelectrical impedance analysis for diagnosing sarcopenia and cachexia: what are we really estimating?. – 2017.
23. Lee K. et al. Recent issues on body composition imaging for sarcopenia evaluation //Korean journal of radiology. – 2019. – V. 20. – №. 2. – P. 205.
24. Stringer H. J., Wilson D. The role of ultrasound as a diagnostic tool for sarcopenia //The Journal of frailty & aging. – 2018. – V. 7. – №. 4. – P. 258-261.
25. Perkisas S. et al. Application of ultrasound for muscle assessment in sarcopenia: towards standardized measurements //European geriatric medicine. – 2018. – V. 9. – №. 6. – P. 739-757.
26. Puthucheary Z. A. et al. Acute skeletal muscle wasting in critical illness //Jama. – 2013. – V. 310. – №. 15. – P. 1591-1600.
27. Cesari M. et al. Biomarkers of sarcopenia in clinical trials—recommendations from the International Working Group on Sarcopenia //Journal of cachexia, sarcopenia and muscle. – 2012. – V. 3. – №. 3. – P. 181-190.
28. Ali N. A. et al. Acquired weakness, handgrip strength, and mortality in critically ill patients //American journal of respiratory and critical care medicine. – 2008. – V. 178. – №. 3. – P. 261-268.
29. De Jonghe B. et al. Respiratory weakness is associated with limb weakness and delayed weaning in critical illness //Critical care medicine. – 2007. – V. 35. – №. 9.
30. Wieske L. et al. Impact of ICU-acquired weakness on post-ICU physical functioning: a follow-up study //Critical Care. – 2015. – V. 19. – №. 1. – P. 1-8.
31. Iwashyna T. J. et al. Long-term cognitive impairment and functional disability among survivors of severe sepsis //Jama. – 2010. – V. 304. – №. 16. – P. 1787-1794.
32. Khan I. M. et al. Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance //International journal of obesity. – 2015. – V. 39. – №. 11. – P. 1607-1618.
33. Lee D. E. et al. Getting the message across: mechanisms of physiological cross talk by adipose tissue //American Journal of Physiology-Endocrinology and Metabolism. – 2009. – V. 296. – №. 6. – P. E1210-E1229.
34. Addison O. et al. Intermuscular fat: a review of the consequences and causes //International journal of endocrinology. – 2014. – V. 2014.
35. Coen P. M., Goodpaster B. H. Role of intramyocelluar lipids in human health //Trends in Endocrinology & Metabolism. – 2012. – V. 23. – №. 8. – P. 391-398.
36. Kizilarslanoglu M. C. et al. Sarcopenia in critically ill patients //Journal of anesthesia. – 2016. – V. 30. – №. 5. – P. 884-890.
37. Wollersheim T. et al. Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness //Intensive care medicine. – 2014. – V. 40. – №. 4. – P. 528-538.
38. Toptas M. et al. The relation between sarcopenia and mortality in patients at intensive care unit //BioMed research international. – 2018. – V. 2018.
39. Zuckerman J. et al. Psoas muscle area and length of stay in older adults undergoing cardiac operations //The Annals of thoracic surgery. – 2017. – V. 103. – №. 5. – P. 1498-1504.
40. Weijs P. J. M. et al. Optimal protein and energy nutrition decreases mortality in mechanically ventilated, critically ill patients: a prospective observational cohort study //Journal of parenteral and enteral nutrition. – 2012. – V. 36. – №. 1. – P. 60-68.
41. Allingstrup M. J. et al. Provision of protein and energy in relation to measured requirements in intensive care patients //Clinical Nutrition. – 2012. – V. 31. – №. 4. – P. 462-468.
42. Hernández-Tejedor A. et al. Recommendations of the Working Groups from the Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC) for the management of adult critically ill patients //Medicina Intensiva (English Edition). – 2017. – V. 41. – №. 5. – P. 285-305.
43. Hoffer L. J., Bistrian B. R. What is the best nutritional support for critically ill patients? //Hepatobiliary surgery and nutrition. – 2014. – V. 3. – №. 4. – P. 172.
44. Segadilha N. L. A. L. et al. Energy expenditure in critically ill elderly patients: indirect calorimetry vs predictive equations //Journal of Parenteral and Enteral Nutrition. – 2017. – V. 41. – №. 5. – P. 776-784.
45. Kayambu G., Boots R., Paratz J. Physical therapy for the critically ill in the ICU: a systematic review and meta-analysis //Read Online: Critical Care Medicine| Society of Critical Care Medicine. – 2013. – V. 41. – №. 6. – P. 1543-1554.
46. Bhasin S. Testosterone supplementation and aging-associated sarcopenia //Endocrine Aspects of Successful Aging: Genes, Hormones and Lifestyles. – 2004. – P. 175-190.
47. BHASIN S., BUCKWALTER J. G. Testosterone supplementation in older men: a rational idea whose time has not yet come //Journal of andrology. – 2001. – V. 22. – №. 5. – P. 718-731.
48. Matsumoto A. M. Andropause: clinical implications of the decline in serum testosterone levels with aging in men //The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. – 2002. – V. 57. – №. 2. – P. M76-M99.
49. Rudman D. et al. Effects of human growth hormone in men over 60 years old //New England Journal of Medicine. – 1990. – V. 323. – №. 1. – P. 1-6.
50. Papadakis M. A. et al. Growth hormone replacement in healthy older men improves body composition but not functional ability //Annals of internal medicine. – 1996. – V. 124. – №. 8. – P. 708-716.
51. Yarasheski K. E., Zachwieja J. J. Growth hormone therapy for the elderly: the fountain of youth proves toxic //Jama. – 1993. – V. 270. – №. 14. – P. 1694-1694. Side effects resulting from the use of growth hormone and insulin-like growth factor-I as combined therapy to frail elderly patients. //J Gerontol – 1998 –53 – 183–7. doi: 10.1093/gerona/53a.3.m183
52. Bonafé L. et al. Carnitine deficiency in chronic critical illness //Current Opinion in Clinical Nutrition & Metabolic Care. – 2014. – V. 17. – №. 2. – P. 200-209.
53. Holeček M. Beta‐hydroxy‐beta‐methylbutyrate supplementation and skeletal muscle in healthy and muscle‐wasting conditions //Journal of cachexia, sarcopenia and muscle. – 2017. – V. 8. – №. 4. – P. 529-541.
54. Morley J. E. Pharmacologic options for the treatment of sarcopenia //Calcified tissue international. – 2016. – V. 98. – №. 4. – P. 319-333.