РЕПРОДУКТИВНАЯ АНДРОЛОГИЯ СЕГОДНЯ: ЧТО СЛЕДУЕТ ЗНАТЬ ГИНЕКОЛОГАМ-РЕПРОДУКТОЛОГАМ?
Клинические рекомендации
Дата публикации: сентября 24, 2020
Ключевые слова
бездетный брак
оксидативный стресс
хроматин сперматозоидов
фрагментация ДНК
оксидативный стресс
хроматин сперматозоидов
фрагментация ДНК
Как цитировать
[1]
В. А. Божедомов, М. А. Машина, Е. И. Шарапова, и А. А. Камалов, РЕПРОДУКТИВНАЯ АНДРОЛОГИЯ СЕГОДНЯ: ЧТО СЛЕДУЕТ ЗНАТЬ ГИНЕКОЛОГАМ-РЕПРОДУКТОЛОГАМ?, КМКВ, вып. 3, сс. 129-137, сен. 2020.
Аннотация
В обзоре представлены современные сведения о роли мужского фактора в возникновении бесплодия, прерывании беременности и врожденных аномалиях у детей в объеме, необходимом врачу-репродуктологу. Приведены современные требования к необходимому объему андрологического обследования мужчин из бездетных пар. Дана характеристика используемых критериев качества спермы: стандартной спермограммы по ВОЗ-2010 и методов оценки функциональных нарушений сперматозоидов. Сформулированы рекомендации для репродуктологов по ведению пар с мужским фактором снижения репродуктивной функции, в том числе современные данные об эффективности различных методов лечения мужского фактора бездетного брака.Литература
1. Rowe P. J. et al. WHO manual for the standardized investigation and diagnosis of the infertile male. – Cambridge university press, 2004.
2. Jungwirth A. et al. Guidelines on male infertility // Eur Urol. – 2015. – V. 42.
3. Agarwal A. et al. A Schematic Overview of the Current Status of Male Infertility Practice // The world journal of men's health. – 2019. – V. 37. doi: 10.5534/wjmh.190068
4. Oseguera-López I. et al. Novel techniques of sperm selection for improving IVF and ICSI outcomes // Frontiers in Cell and Developmental Biology. – 2019. – V. 7. doi: 10.3389/fcell.2019.00298
5. Belloc S. et al. Sperm deoxyribonucleic acid damage in normozoospermic men is related to age and sperm progressive motility // Fertility and sterility. – 2014. – V. 101. – №. 6. – P. 1588-1593. doi: 10.1016/j.fertnstert.2014.02.006
6. Сухих Г. Т., Божедомов В. А. МУЖСКОЕ БЕСПЛОДИЕ. Практическое руководство для урологов и гинекологов, М.: Эксмо, 2009; С. 240 // Медицинская практика. – 2009. [Sukhikh G.T., Bozhedomov V.A. Male infertility. A Practical Guide for urologists and gynecologists, M.: Eksmo, 2009; P. 240. In Russian].
7. Zini A., Agarwal A. (ed.). Sperm chromatin: biological and clinical applications in male infertility and assisted reproduction. – New York, NY: Springer, 2011. – P. 512.
8. RECURRENT PREGNANCY LOSS. ESHRE Early Pregnancy Guidline Development Group. Guideline of the European Society of Human Reproduction and Embryology, 2019: P. 81-84.
9. Esteves S. C., Chan P. A systematic review of recent clinical practice guidelines and best practice statements for the evaluation of the infertile male // International urology and nephrology. – 2015. – V. 47. – №. 9. – P. 1441-1456.
10. Andrology: Male Reproductive Health and Disfunction. 3rd. E.Nieschlag., H.M.Behre, S.Nieschlag (Ed.), 2010; 629.
11. WHO laboratory manual for the examination and processing of human semen. Fifth ed., WHO, 2010; 271.
12. Божедомов В. А. Мужской фактор бездетного брака–пути решения проблемы // Урология. – 2016. – Т. 1. – С. 29-35. [V.A. Bozhedomov Male factor in childless marriage - ways of solving the problem. Urology, 2016, 1, P. 29-35. In Russian]
13. Krausz C., Riera-Escamilla A. Genetics of male infertility // Nature Reviews Urology. – 2018. – V. 15. – №. 6. – P. 369-384.
14. Kaya C. et al. The effect of modifiable lifestyle factors on semen quality // Revista Internacional de Andrología. – 2020. doi: 10.1016/j.androl.2019.09.001
15. Barratt C. L. R. et al. The diagnosis of male infertility: an analysis of the evidence to support the development of global WHO guidance—challenges and future research opportunities // Human reproduction update. – 2017. – V. 23. – №. 6. – P. 660-680. doi: 10.1093/humupd/dmx021
16. De Jonge C. J., Barratt C. L. R. // The Sperm Cell: Production, Maturation, Fertilization, Regeneration. – 2017. P. 304.
17. Practice Committee of American Society for Reproductive Medicine in collaboration with Society for Male Reproduction and Urology. Evaluation of the azoospermic male. Fertil Steril. 2008;90(5 Suppl):S74–7.
18. Weidner W, Diemer Th, Wagenlehner W. Male urogenital infection // Clinical Uro-Andrology. Ed. V.Mirone-Springer Cham Heidelberg New York Dordrecht London, 2015, P. 205-212.
19. Божедомов В. А. и др. Репродуктивная функция мужчин при хроническом простатите: клинико-анамнестические и микробиологические аспекты // Урология. – 2015. – Т. 1. – С. 70-78 [V.A. Bozhedomov, A.V. Semenov, G.E. Bozhedomova and co. Reproductive function of men with chronic prostatitis: clinical, medical history and microbiological aspects. Urology, 2015; 1; P. 70-78. In Russian]
20. Elbardisi H. et al. Predictive value of oxidative stress testing in semen for sperm DNA fragmentation assessed by sperm chromatin dispersion test. Andrology. 2019.
21. McQueen D. B., Zhang J., Robins J. C. Sperm DNA fragmentation and recurrent pregnancy loss: a systematic review and meta-analysis // Fertility and sterility. – 2019. – V. 112. – №. 1. – P. 54-60. e3. doi: 10.1016/j.fertnstert.2019.03.003
22. Marcho C., Oluwayiose O. A., Pilsner J. R. The preconception environment and sperm epigenetics // Andrology. – 2020. doi: 10.1111/andr.12753
23. Zini A. et al. Potential adverse effect of sperm DNA damage on embryo quality after ICSI // Human Reproduction. – 2005. – V. 20. – №. 12. – P. 3476-3480. doi: 10.1093/humrep/dei266
24. Kumar K. et al. Predictive value of DNA integrity analysis in idiopathic recurrent pregnancy loss following spontaneous conception // Journal of assisted reproduction and genetics. – 2012. – V. 29. – №. 9. – P. 861-867.
25. Дударова А.Х. et al. Различные методики селекции мужских половых клеток и их взаимосвязь с результатами программ ВРТ.// Акушерство и гинекология. 2017. – № 7.-С. 96-103 [A.H. Dudarova, V.U. Smolnikova, N.P. Makarova and co. Different methods for male germ cell selection and their relationship with the results of ART programs. Obstetrics an gynecology, 2017. №7.- P. 96-103. In Russian].
26. Showell M. G. et al. Antioxidants for male subfertility // Cochrane Database of Systematic Reviews. – 2014. – №. 12.
doi: 10.1002/14651858.CD007411.pub3.
27. Feijó C. M., Esteves S. C. Diagnostic accuracy of sperm chromatin dispersion test to evaluate sperm deoxyribonucleic acid damage in men with unexplained infertility // Fertility and Sterility. – 2014. – V. 101. – №. 1. – P. 58-63. e3.
doi: 10.1016/j.fertnstert.2013.09.002.
28. Божедомов В. А. и др. Активные формы кислорода и репродуктивная функция мужчин: фундаментальные и клинические аспекты (обзор литературы) // Андрология и генитальная хирургия. – 2011. – Т. 3. – С. 10-16 [V.A. Bozhedomov, M.V. Toroptsev, I.V. Ushakov and co. Active forms of oxygen and the reproductive function of men: fundamental and clinical aspects. Andrology and Genital Surgery – 2011. – V. 3. – P. 26-33. In Russian].
29. Aitken R. J. Reactive oxygen species as mediators of sperm capacitation and pathological damage // Molecular reproduction and development. – 2017. – V. 84. – №. 10. – P. 1039-1052. doi: 10.1002/mrd.22871.
30. Божедомов В.А., Липатова Н.А., Спориш Е.А. Роль структурных нарушений хроматина и ДНК сперматозоидов в развитии бесплодия // Андрология и генитальная хирургия. - 2012. - №3. - С. 80-90. [Bozhedomov V.A., Lipatova N.A., Sporish E.A. The role of structural disorders of chromatin and DNA of sperm in the development of infertility. Andrology and genital surgery. - 2012. - No. 3. - S. 80-90. In Russian]
31. Esteves S. C., Miyaoka R., Agarwal A. An update on the clinical assessment of the infertile male // Clinics. – 2011. – V. 66. – №. 4. – P. 691-700. doi: 10.1590/S1807-59322011000400026.
32. Приказ Министерства здравоохранения РФ от 30 августа 2012 г. № 107н «О порядке использования вспомогательных репродуктивных технологий, противопоказаниях и ограничениях к их применению. [Order of the Ministry of Health of the Russian Federation 30th of August 2012 №107n, «On the procedure for using assisted reproductive technologies, contraindications and restrictions on their use». In Russian]
33. Neri Q. V. et al. Understanding the spermatozoon // Human Fertility. – Humana Press, New York, NY, 2014. – P. 91-119.
34. Bozhedomov V. A. et al. Functional deficit of sperm and fertility impairment in men with antisperm antibodies // Journal of reproductive immunology. – 2015. – V. 112. – P. 95-101. doi: 10.1016/j.jri.2015.08.002
35. Bozhedomov V. A. et al. The role of the antisperm antibodies in male infertility assessment after microsurgical varicocelectomy // Andrology. – 2014. – V. 2. – №. 6. – P. 847-855. doi: 10.1111/j.2047-2927.2014.00254.x
36. Salas-Huetos A., Bulló M., Salas-Salvadó J. Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies // Human reproduction update. – 2017. – V. 23. – №. 4. – P. 371-389. doi: 10.1093/humupd/dmx006
37. Adams J. A. et al. Effect of mobile telephones on sperm quality: a systematic review and meta-analysis // Environment international. – 2014. – V. 70. – P. 106-112. doi: 10.1016/j.envint.2014.04.015
38. Smits R. M. et al. Antioxidants for male subfertility // Cochrane Database of Systematic Reviews. – 2019. – №. 3. doi: 10.1002/14651858.CD007411.pub4.
39. Божедомов В. А. и др. Применение комплекса нутриентов при идиопатическом мужском бесплодии в форме астено-и/или тератозооспермии: поиск предикторов эффективности лечения (предварительные результаты) // Урология. – 2018. – №. 5. – С. 53-59. [Bozhedomov V.A. et al. The use of a complex of nutrients in idiopathic male infertility in the form of astheno- and / or teratozoospermia: the search for predictors of treatment effectiveness (preliminary results). Urology – 2018. – №. 5. – P. 53-59. In Russian]
40. Machen G. L. et al. Time to improvement of semen parameters after microscopic varicocelectomy: When it occurs and its effects on fertility // Andrologia. – 2020. – V. 52. – №. 2. – P. E13500. doi: 10.1111/and.13500
41. Esteves S. C., Oliveira F. V., Bertolla R. P. Clinical outcome of intracytoplasmic sperm injection in infertile men with treated and untreated clinical varicocele // The Journal of urology. – 2010. – V. 184. – №. 4. – P. 1442-1446. doi: 10.1016/j.juro.2010.06.004
42. Bahadur G. et al. Observational retrospective study of UK national success, risks and costs for 319,105 IVF/ICSI and 30,669 IUI treatment cycles // BMJ open. – 2020. – V. 10. – №. 3. – P. E034566. doi: 10.1136/bmjopen-2019-034566.
43. Аншина, М. Б. Если вам нужен ребенок. Бесплодие, ЭКО, ИКСИ // М.: Дипак. – 2010. – P. 56-68. [M.B. Anshina “If you need a child” Infertility, IVF, ICSI // Moscow: Dipak. – 2010. – P. 56-68. In Russian]
44. Zhang Z. et al. Predictors of pregnancy outcome for infertile couples attending IVF and ICSI programmes // Andrologia. – 2016. – V. 48. – №. 9. – P. 962-969. doi: 10.1111/and.12525
2. Jungwirth A. et al. Guidelines on male infertility // Eur Urol. – 2015. – V. 42.
3. Agarwal A. et al. A Schematic Overview of the Current Status of Male Infertility Practice // The world journal of men's health. – 2019. – V. 37. doi: 10.5534/wjmh.190068
4. Oseguera-López I. et al. Novel techniques of sperm selection for improving IVF and ICSI outcomes // Frontiers in Cell and Developmental Biology. – 2019. – V. 7. doi: 10.3389/fcell.2019.00298
5. Belloc S. et al. Sperm deoxyribonucleic acid damage in normozoospermic men is related to age and sperm progressive motility // Fertility and sterility. – 2014. – V. 101. – №. 6. – P. 1588-1593. doi: 10.1016/j.fertnstert.2014.02.006
6. Сухих Г. Т., Божедомов В. А. МУЖСКОЕ БЕСПЛОДИЕ. Практическое руководство для урологов и гинекологов, М.: Эксмо, 2009; С. 240 // Медицинская практика. – 2009. [Sukhikh G.T., Bozhedomov V.A. Male infertility. A Practical Guide for urologists and gynecologists, M.: Eksmo, 2009; P. 240. In Russian].
7. Zini A., Agarwal A. (ed.). Sperm chromatin: biological and clinical applications in male infertility and assisted reproduction. – New York, NY: Springer, 2011. – P. 512.
8. RECURRENT PREGNANCY LOSS. ESHRE Early Pregnancy Guidline Development Group. Guideline of the European Society of Human Reproduction and Embryology, 2019: P. 81-84.
9. Esteves S. C., Chan P. A systematic review of recent clinical practice guidelines and best practice statements for the evaluation of the infertile male // International urology and nephrology. – 2015. – V. 47. – №. 9. – P. 1441-1456.
10. Andrology: Male Reproductive Health and Disfunction. 3rd. E.Nieschlag., H.M.Behre, S.Nieschlag (Ed.), 2010; 629.
11. WHO laboratory manual for the examination and processing of human semen. Fifth ed., WHO, 2010; 271.
12. Божедомов В. А. Мужской фактор бездетного брака–пути решения проблемы // Урология. – 2016. – Т. 1. – С. 29-35. [V.A. Bozhedomov Male factor in childless marriage - ways of solving the problem. Urology, 2016, 1, P. 29-35. In Russian]
13. Krausz C., Riera-Escamilla A. Genetics of male infertility // Nature Reviews Urology. – 2018. – V. 15. – №. 6. – P. 369-384.
14. Kaya C. et al. The effect of modifiable lifestyle factors on semen quality // Revista Internacional de Andrología. – 2020. doi: 10.1016/j.androl.2019.09.001
15. Barratt C. L. R. et al. The diagnosis of male infertility: an analysis of the evidence to support the development of global WHO guidance—challenges and future research opportunities // Human reproduction update. – 2017. – V. 23. – №. 6. – P. 660-680. doi: 10.1093/humupd/dmx021
16. De Jonge C. J., Barratt C. L. R. // The Sperm Cell: Production, Maturation, Fertilization, Regeneration. – 2017. P. 304.
17. Practice Committee of American Society for Reproductive Medicine in collaboration with Society for Male Reproduction and Urology. Evaluation of the azoospermic male. Fertil Steril. 2008;90(5 Suppl):S74–7.
18. Weidner W, Diemer Th, Wagenlehner W. Male urogenital infection // Clinical Uro-Andrology. Ed. V.Mirone-Springer Cham Heidelberg New York Dordrecht London, 2015, P. 205-212.
19. Божедомов В. А. и др. Репродуктивная функция мужчин при хроническом простатите: клинико-анамнестические и микробиологические аспекты // Урология. – 2015. – Т. 1. – С. 70-78 [V.A. Bozhedomov, A.V. Semenov, G.E. Bozhedomova and co. Reproductive function of men with chronic prostatitis: clinical, medical history and microbiological aspects. Urology, 2015; 1; P. 70-78. In Russian]
20. Elbardisi H. et al. Predictive value of oxidative stress testing in semen for sperm DNA fragmentation assessed by sperm chromatin dispersion test. Andrology. 2019.
21. McQueen D. B., Zhang J., Robins J. C. Sperm DNA fragmentation and recurrent pregnancy loss: a systematic review and meta-analysis // Fertility and sterility. – 2019. – V. 112. – №. 1. – P. 54-60. e3. doi: 10.1016/j.fertnstert.2019.03.003
22. Marcho C., Oluwayiose O. A., Pilsner J. R. The preconception environment and sperm epigenetics // Andrology. – 2020. doi: 10.1111/andr.12753
23. Zini A. et al. Potential adverse effect of sperm DNA damage on embryo quality after ICSI // Human Reproduction. – 2005. – V. 20. – №. 12. – P. 3476-3480. doi: 10.1093/humrep/dei266
24. Kumar K. et al. Predictive value of DNA integrity analysis in idiopathic recurrent pregnancy loss following spontaneous conception // Journal of assisted reproduction and genetics. – 2012. – V. 29. – №. 9. – P. 861-867.
25. Дударова А.Х. et al. Различные методики селекции мужских половых клеток и их взаимосвязь с результатами программ ВРТ.// Акушерство и гинекология. 2017. – № 7.-С. 96-103 [A.H. Dudarova, V.U. Smolnikova, N.P. Makarova and co. Different methods for male germ cell selection and their relationship with the results of ART programs. Obstetrics an gynecology, 2017. №7.- P. 96-103. In Russian].
26. Showell M. G. et al. Antioxidants for male subfertility // Cochrane Database of Systematic Reviews. – 2014. – №. 12.
doi: 10.1002/14651858.CD007411.pub3.
27. Feijó C. M., Esteves S. C. Diagnostic accuracy of sperm chromatin dispersion test to evaluate sperm deoxyribonucleic acid damage in men with unexplained infertility // Fertility and Sterility. – 2014. – V. 101. – №. 1. – P. 58-63. e3.
doi: 10.1016/j.fertnstert.2013.09.002.
28. Божедомов В. А. и др. Активные формы кислорода и репродуктивная функция мужчин: фундаментальные и клинические аспекты (обзор литературы) // Андрология и генитальная хирургия. – 2011. – Т. 3. – С. 10-16 [V.A. Bozhedomov, M.V. Toroptsev, I.V. Ushakov and co. Active forms of oxygen and the reproductive function of men: fundamental and clinical aspects. Andrology and Genital Surgery – 2011. – V. 3. – P. 26-33. In Russian].
29. Aitken R. J. Reactive oxygen species as mediators of sperm capacitation and pathological damage // Molecular reproduction and development. – 2017. – V. 84. – №. 10. – P. 1039-1052. doi: 10.1002/mrd.22871.
30. Божедомов В.А., Липатова Н.А., Спориш Е.А. Роль структурных нарушений хроматина и ДНК сперматозоидов в развитии бесплодия // Андрология и генитальная хирургия. - 2012. - №3. - С. 80-90. [Bozhedomov V.A., Lipatova N.A., Sporish E.A. The role of structural disorders of chromatin and DNA of sperm in the development of infertility. Andrology and genital surgery. - 2012. - No. 3. - S. 80-90. In Russian]
31. Esteves S. C., Miyaoka R., Agarwal A. An update on the clinical assessment of the infertile male // Clinics. – 2011. – V. 66. – №. 4. – P. 691-700. doi: 10.1590/S1807-59322011000400026.
32. Приказ Министерства здравоохранения РФ от 30 августа 2012 г. № 107н «О порядке использования вспомогательных репродуктивных технологий, противопоказаниях и ограничениях к их применению. [Order of the Ministry of Health of the Russian Federation 30th of August 2012 №107n, «On the procedure for using assisted reproductive technologies, contraindications and restrictions on their use». In Russian]
33. Neri Q. V. et al. Understanding the spermatozoon // Human Fertility. – Humana Press, New York, NY, 2014. – P. 91-119.
34. Bozhedomov V. A. et al. Functional deficit of sperm and fertility impairment in men with antisperm antibodies // Journal of reproductive immunology. – 2015. – V. 112. – P. 95-101. doi: 10.1016/j.jri.2015.08.002
35. Bozhedomov V. A. et al. The role of the antisperm antibodies in male infertility assessment after microsurgical varicocelectomy // Andrology. – 2014. – V. 2. – №. 6. – P. 847-855. doi: 10.1111/j.2047-2927.2014.00254.x
36. Salas-Huetos A., Bulló M., Salas-Salvadó J. Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies // Human reproduction update. – 2017. – V. 23. – №. 4. – P. 371-389. doi: 10.1093/humupd/dmx006
37. Adams J. A. et al. Effect of mobile telephones on sperm quality: a systematic review and meta-analysis // Environment international. – 2014. – V. 70. – P. 106-112. doi: 10.1016/j.envint.2014.04.015
38. Smits R. M. et al. Antioxidants for male subfertility // Cochrane Database of Systematic Reviews. – 2019. – №. 3. doi: 10.1002/14651858.CD007411.pub4.
39. Божедомов В. А. и др. Применение комплекса нутриентов при идиопатическом мужском бесплодии в форме астено-и/или тератозооспермии: поиск предикторов эффективности лечения (предварительные результаты) // Урология. – 2018. – №. 5. – С. 53-59. [Bozhedomov V.A. et al. The use of a complex of nutrients in idiopathic male infertility in the form of astheno- and / or teratozoospermia: the search for predictors of treatment effectiveness (preliminary results). Urology – 2018. – №. 5. – P. 53-59. In Russian]
40. Machen G. L. et al. Time to improvement of semen parameters after microscopic varicocelectomy: When it occurs and its effects on fertility // Andrologia. – 2020. – V. 52. – №. 2. – P. E13500. doi: 10.1111/and.13500
41. Esteves S. C., Oliveira F. V., Bertolla R. P. Clinical outcome of intracytoplasmic sperm injection in infertile men with treated and untreated clinical varicocele // The Journal of urology. – 2010. – V. 184. – №. 4. – P. 1442-1446. doi: 10.1016/j.juro.2010.06.004
42. Bahadur G. et al. Observational retrospective study of UK national success, risks and costs for 319,105 IVF/ICSI and 30,669 IUI treatment cycles // BMJ open. – 2020. – V. 10. – №. 3. – P. E034566. doi: 10.1136/bmjopen-2019-034566.
43. Аншина, М. Б. Если вам нужен ребенок. Бесплодие, ЭКО, ИКСИ // М.: Дипак. – 2010. – P. 56-68. [M.B. Anshina “If you need a child” Infertility, IVF, ICSI // Moscow: Dipak. – 2010. – P. 56-68. In Russian]
44. Zhang Z. et al. Predictors of pregnancy outcome for infertile couples attending IVF and ICSI programmes // Andrologia. – 2016. – V. 48. – №. 9. – P. 962-969. doi: 10.1111/and.12525